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Tbio
SHANK3
SH3 and multiple ankyrin repeat domains protein 3

Protein Summary
Description
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000635818
  • ENSP00000490818
  • ENSG00000283243
  • ENST00000645837
  • ENSP00000495774

Symbol
  • KIAA1650
  • PROSAP2
  • PSAP2
  • PSAP2
  • SCZD15
  • PROSAP2
  • SPANK-2
  • DEL22q13.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
protein domain
0.97
cellular component
0.77
molecular function
0.76
histone modification site profile
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 and multiple ankyrin repeat domains 3
VGNC:12921
100614904
Mouse
MGI:1930016
58234
Rat
RGD:69264
59312
Horse
SH3 and multiple ankyrin repeat domains 3
VGNC:22953
100056993
Cow
SH3 and multiple ankyrin repeat domains 3
VGNC:34586
512428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 and multiple ankyrin repeat domains 3
Mouse
Rat
Horse
SH3 and multiple ankyrin repeat domains 3
Cow
SH3 and multiple ankyrin repeat domains 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYB0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (51)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (16)
1 – 10 of 16
ARHGAP12
Tbio
Family: Enzyme
Novelty: 0.12113722
p_int: 0.999999946
p_ni: 5e-9
p_wrong: 4.8e-8
Data Source: BioPlex
PRMT2
Tbio
Family: Epigenetic
Novelty: 0.04121581
p_int: 0.999987499
p_ni: 1.41e-7
p_wrong: 0.000012359
Data Source: BioPlex
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Data Source: Reactome
HOMER3
Tbio
Novelty: 0.04408998
Data Source: Reactome
DBNL
Tbio
Novelty: 0.03390948
Data Source: Reactome
DLGAP4
Tbio
Novelty: 0.06240351
Data Source: Reactome
DLG3
Tbio
Novelty: 0.01196565
Data Source: Reactome
DLG4
Tchem
Novelty: 0.00057285
Data Source: Reactome
GRM1
Tchem
Family: GPCR
Novelty: 0.00099764
Data Source: Reactome
HOMER1
Tbio
Novelty: 0.00264721
Data Source: Reactome
Publication Statistics
PubTator Score  163.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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