DUSP16
Dual specificity protein phosphatase 16
Protein Summary
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
- ENST00000228862
- ENSP00000228862
- ENSG00000111266
- ENST00000298573
- ENSP00000298573
- ENST00000626413
- ENSP00000487512
- ENSG00000280962
- ENST00000628303
- ENSP00000487034
- KIAA1700
- MKP7
- MKP7
- MKP-7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
virus perturbation | 0.92 | ||
transcription factor binding site profile | 0.86 | ||
transcription factor perturbation | 0.84 | ||
drug perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.38 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 203 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.38 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 203 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (34)
MAPK14
Family: Kinase
Novelty: 0.00045138
p_int: 0.999643315
p_ni: 0.000040285
p_wrong: 0.0003164
Score: 0.994
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (295)
Reactome (11)
KEGG (1)
PathwayCommons (2)
WikiPathways (281)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Immune System | ||||
Reactome | MAPK family signaling cascades | ||||
Reactome | MAPK1/MAPK3 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Immune System | ||||
MAPK family signaling cascades | ||||
MAPK1/MAPK3 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (5)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
balding measurement | 1 | 1 | 1 | 54.4 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 46.9 | |||||
lymphocyte count | 1 | 1 | 1 | 46.1 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 44.2 | |||||
1 | 1 | 0 | 1.1 | 24.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
balding measurement | 1 | 54.4 | |||||
lymphocyte percentage of leukocytes | 1 | 46.9 | |||||
lymphocyte count | 1 | 46.1 | |||||
neutrophil percentage of leukocytes | 1 | 44.2 | |||||
0 | 1.1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dual specificity phosphatase 16 | VGNC:51252 | 465297 | |||||
Macaque | dual specificity phosphatase 16 | 696332 | ||||||
Mouse | MGI:1917936 | 70686 | ||||||
Rat | RGD:1310721 | 297682 | ||||||
Dog | dual specificity phosphatase 16 | VGNC:40130 | 486683 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dual specificity phosphatase 16 | |||||
Macaque | dual specificity phosphatase 16 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dual specificity phosphatase 16 | |||||
Publication Statistics
PubMed Score 39.38
PubMed score by year
PubTator Score 21.66
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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