Tbio MFRP Membrane frizzled-related protein

Protein Summary

Description

May play a role in eye development. This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q9BY79
• B0YJ36
• B0YJ37
• B4DHN8
• Q335M3
• Q96DQ9

Gene Name

• MFRP

Ensembl ID

• ENST00000360167
• ENSP00000353291
• ENSG00000235718
• ENST00000619721
• ENSP00000481824

Symbol

• RD6
• NNO2
• CTRP5
• MCOP5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.64
cell type or tissue	0.6
protein domain	0.58
cell line	0.54
PubMedID	0.49

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Membrane Frizzled-related Protein

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Membrane Frizzled-related Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.85   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.85   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0