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Tbio
POLDIP3
Polymerase delta-interacting protein 3

Protein Summary
Description
Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252115
  • ENSP00000252115
  • ENSG00000100227
  • ENST00000348657
  • ENSP00000252116

Symbol
  • KIAA1649
  • PDIP46
  • SKAR
  • PDIP3
  • PDIP46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
transcription factor perturbation
0.98
kinase perturbation
0.96
transcription factor binding site profile
0.89
interacting protein
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.81   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.81   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase delta interacting protein 3
VGNC:8864
458882
Mouse
MGI:1921076
73826
Rat
RGD:1311073
315170
Dog
DNA polymerase delta interacting protein 3
VGNC:44778
474480
Horse
DNA polymerase delta interacting protein 3
VGNC:21655
100071034
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase delta interacting protein 3
Mouse
Rat
Dog
DNA polymerase delta interacting protein 3
Horse
DNA polymerase delta interacting protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BY77-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (197)
1 – 10 of 197
CYB5D2
Tbio
Novelty: 0.23122479
p_int: 0.966584135
p_ni: 0.033415864
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
SARNP
Tbio
Novelty: 0.00987312
p_int: 0.926541538
p_ni: 0.073458388
p_wrong: 7.4e-8
Score: 0.97
Data Source: BioPlex,STRINGDB
KLHL20
Tbio
Novelty: 0.12205871
p_int: 0.920897563
p_ni: 0.078920284
p_wrong: 0.000182153
Score: 0.311
Data Source: BioPlex,STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
p_int: 0.890721837
p_ni: 0.109278163
Score: 0.177
Data Source: BioPlex,STRINGDB
KLHL22
Tbio
Novelty: 0.24456252
p_int: 0.78703203
p_ni: 0.21296797
Score: 0.457
Data Source: BioPlex,STRINGDB
RPS6KB1
Tchem
Family: Kinase
Novelty: 0.00044681
Score: 0.993
Data Source: STRINGDB
DDX39B
Tbio
Family: Enzyme
Novelty: 0.012548
Score: 0.99
Data Source: STRINGDB
EIF4A3
Tbio
Novelty: 0.00981496
Score: 0.987
Data Source: STRINGDB
DDX39A
Tbio
Family: Enzyme
Novelty: 0.0373703
Score: 0.987
Data Source: STRINGDB
NCBP1
Tbio
Novelty: 0.01228885
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  33.81

PubMed score by year
PubTator Score  16.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer