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Tbio
ANGPTL4
Angiopoietin-related protein 4

Protein Summary
Description
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301455
  • ENSP00000301455
  • ENSG00000167772
  • ENST00000393962
  • ENSP00000377534
  • ENST00000593998
  • ENSP00000472551

Symbol
  • ARP4
  • HFARP
  • PGAR
  • NL2
  • ARP4
  • FIAF
  • HARP
  • PGAR
  • HFARP
  • TGQTL
  • UNQ171
  • pp1158
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
PubMedID
0.84
biological term
0.82
protein domain
0.73
kinase perturbation
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.91   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.91   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0