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Tbio
ANGPTL4
Angiopoietin-related protein 4

Protein Classes
Protein Summary
Description
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301455
  • ENSP00000301455
  • ENSG00000167772
  • ENST00000393962
  • ENSP00000377534
  • ENST00000593998
  • ENSP00000472551

Symbol
  • ARP4
  • HFARP
  • PGAR
  • NL2
  • ARP4
  • FIAF
  • HARP
  • PGAR
  • HFARP
  • TGQTL
  • UNQ171
  • pp1158
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
PubMedID
0.84
biological term
0.82
protein domain
0.73
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.84   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.84   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
4
13
4
98.3
triglyceride measurement
8
1
9
95
red blood cell distribution width
2
1
2
80.1
apolipoprotein A 1 measurement
1
2
2
76
metabolic syndrome
1
1
1
73.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
4
98.3
triglyceride measurement
9
95
red blood cell distribution width
2
80.1
apolipoprotein A 1 measurement
2
76
metabolic syndrome
1
73.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiopoietin like 4
VGNC:2088
743667
Mouse
MGI:1888999
57875
Rat
RGD:735058
362850
Dog
angiopoietin like 4
VGNC:37860
476724
Horse
angiopoietin like 4
100067036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiopoietin like 4
Mouse
Rat
Dog
angiopoietin like 4
Horse
angiopoietin like 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BY76-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (134)
1 – 10 of 134
WDR47
Tdark
Novelty: 0.51632776
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.999382286
p_ni: 0.000617714
Score: 0.173
Data Source: BioPlex,STRINGDB
PM20D2
Tdark
Family: Enzyme
Novelty: 0.63491472
p_int: 0.991501179
p_ni: 0.008498821
Score: 0.228
Data Source: BioPlex,STRINGDB
AASDHPPT
Tbio
Family: Enzyme
Novelty: 0.00443438
p_int: 0.981770618
p_ni: 0.018229382
Score: 0.19
Data Source: BioPlex,STRINGDB
NMT1
Tchem
Family: Enzyme
Novelty: 0.00343834
p_int: 0.888624603
p_ni: 0.111375397
Score: 0.163
Data Source: BioPlex,STRINGDB
ITIH2
Tbio
Novelty: 0.04886358
p_int: 0.805003396
p_ni: 0.193965169
p_wrong: 0.001031435
Score: 0.198
Data Source: BioPlex,STRINGDB
ARMC8
Tbio
Novelty: 0.06820746
p_int: 0.786601189
p_ni: 0.213398811
Data Source: BioPlex
DNAJB4
Tbio
Novelty: 0.03467352
p_int: 0.775667237
p_ni: 0.224332763
Score: 0.186
Data Source: BioPlex,STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.987
Data Source: STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  541.84

PubMed score by year
PubTator Score  228.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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