Tbio ANGPTL4 Angiopoietin-related protein 4

Protein Summary

Description

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q9BY76
• A8MY84
• B4E089
• D6W670
• F5H0I2
• Q53HQ6
• Q53HU1
• Q6UXN0
• Q9HBV4
• Q9NZU4
• Q9Y5B3

Gene Name

• ANGPTL4

Ensembl ID

• ENST00000301455
• ENSP00000301455
• ENSG00000167772
• ENST00000393962
• ENSP00000377534
• ENST00000593998
• ENSP00000472551

Symbol

• ARP4
• HFARP
• PGAR
• NL2
• ARP4
• FIAF
• HARP
• PGAR
• HFARP
• TGQTL
• UNQ171
• pp1158

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
PubMedID	0.84
biological term	0.82
protein domain	0.73
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Angiopoietin-related Protein 4

DTO Classes

Protein / Signaling / Angiopoietin-related Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.91   (req: < 5)

Gene RIFs: 230   (req: <= 3)

Antibodies: 470   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.91   (req: >= 5)

Gene RIFs: 230   (req: > 3)

Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0