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Tbio
CADM1
Cell adhesion molecule 1

Protein Summary
Description
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the sperm ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331581
  • ENSP00000329797
  • ENSG00000182985
  • ENST00000452722
  • ENSP00000395359
  • ENST00000537058
  • ENSP00000439817
  • ENST00000542447
  • ENSP00000439176

Symbol
  • IGSF4
  • IGSF4A
  • NECL2
  • SYNCAM
  • TSLC1
  • BL2
  • ST17
  • IGSF4
  • NECL2
  • RA175
  • TSLC1
  • IGSF4A
  • Necl-2
  • SYNCAM
  • sgIGSF
  • sTSLC-1
  • synCAM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.97
biological term
0.88
biological process
0.85
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 919.8   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 573   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 919.8   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 573   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
9
97.2
body mass index
9
2
11
79.3
comparative body size at age 10, self-reported
1
1
1
65.6
3
3
2
1.1
63.1
age at menarche
2
2
2
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
97.2
body mass index
11
79.3
comparative body size at age 10, self-reported
1
65.6
2
1.1
63.1
age at menarche
2
58.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule 1
VGNC:11273
740761
Macaque
cell adhesion molecule 1
695983
Mouse
MGI:1889272
54725
Rat
RGD:1310999
363058
Dog
cell adhesion molecule 1
VGNC:38655
479432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule 1
Macaque
cell adhesion molecule 1
Mouse
Rat
Dog
cell adhesion molecule 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BY67-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Nectin/Necl trans heterodimerization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Nectin/Necl trans heterodimerization
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (106)
1 – 10 of 106
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.948780913
p_ni:  0.051219087
Score:  0.19
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
Score:  0.994
Data Source:  STRINGDB
NECTIN3
Tbio
Novelty:  0.01288113
Score:  0.922
Data Source:  Reactome,STRINGDB
CRTAM
Tbio
Novelty:  0.06192285
Score:  0.917
Data Source:  STRINGDB
CADM3
Tbio
Novelty:  0.01907524
Score:  0.916
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.906
Data Source:  STRINGDB
EPB41
Tbio
Novelty:  0.0013288
Score:  0.831
Data Source:  STRINGDB
EPB41L1
Tbio
Novelty:  0.02937451
Score:  0.817
Data Source:  STRINGDB
MPP3
Tbio
Novelty:  0.0284013
Score:  0.813
Data Source:  STRINGDB
EPB41L2
Tbio
Novelty:  0.0311733
Score:  0.804
Data Source:  STRINGDB
Publication Statistics
PubMed Score  919.80

PubMed score by year
PubTator Score  330.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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