Tbio KDM5D Lysine-specific demethylase 5D

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• Q9BY66
• A2RU19
• A6H8V7
• B7ZLX1
• Q92509
• Q92809
• Q9HCU1

Gene Name

• KDM5D

Ensembl ID

• ENST00000317961
• ENSP00000322408
• ENSG00000012817
• ENST00000382806
• ENSP00000372256
• ENST00000541639
• ENSP00000444293

Symbol

• HY
• HYA
• JARID1D
• KIAA0234
• SMCY
• HY
• HYA
• SMCY
• JARID1D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
gene perturbation	0.76
transcription factor perturbation	0.68
molecular function	0.67
small molecule perturbation	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase 5d

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase 5d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 40   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0