You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UGT2B28
UDP-glucuronosyltransferase 2B28

Protein Summary
Description
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active. This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335568
  • ENSP00000334276
  • ENSG00000135226
  • ENST00000511240
  • ENSP00000427399
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
cell line
0.65
pathway
0.61
cellular component
0.56
metabolite
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
MIS18A
Tbio
Novelty:  0.08143008
Score:  0.8
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.783
Data Source:  STRINGDB
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
Score:  0.782
Data Source:  STRINGDB
SRD5A2
Tclin
Family:  Enzyme
Novelty:  0.00281044
Score:  0.764
Data Source:  STRINGDB
CYP3A7
Tclin
Family:  Enzyme
Novelty:  0.00736888
Score:  0.752
Data Source:  STRINGDB
CYP2A13
Tchem
Novelty:  0.00697238
Score:  0.75
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.749
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.737
Data Source:  STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.73
Data Source:  STRINGDB
CYP2C8
Tchem
Novelty:  0.00186373
Score:  0.728
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (16)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
22.8
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 14.71
PubMed score by year
PubTator Score 8.90
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title