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Tdark
SEC11C
Signal peptidase complex catalytic subunit SEC11C

Protein Classes
Protein Summary
Description
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000587834
  • ENSP00000468633
  • ENSG00000166562

Symbol
  • SEC11L3
  • SPC21
  • SPCS4C
  • SPC21
  • SPCS4C
  • SEC11L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
small molecule perturbation
0.84
histone modification site profile
0.81
transcription factor perturbation
0.74
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
2
1.1
91.5
3
3
2
1.1
56.2
body mass index
5
1
6
30.1
insomnia measurement
1
1
0
1
14.2
appendicular lean mass
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
91.5
2
1.1
56.2
body mass index
6
30.1
insomnia measurement
0
1
14.2
appendicular lean mass
1
8.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SEC11 homolog C, signal peptidase complex subunit
696739
Mouse
MGI:1913536
66286
Rat
RGD:628665
266758
Dog
SEC11 homolog C, signal peptidase complex subunit
VGNC:45961
404003
Horse
SEC11 homolog C, signal peptidase complex subunit
VGNC:22782
100054810
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SEC11 homolog C, signal peptidase complex subunit
Mouse
Rat
Dog
SEC11 homolog C, signal peptidase complex subunit
Horse
SEC11 homolog C, signal peptidase complex subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BY50-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Incretin synthesis, secretion, and inactivation (R-HSA-400508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Synthesis, secretion, and deacylation of Ghrelin
Name
Explore in Pharos
Explore in Source
Incretin synthesis, secretion, and inactivation
Metabolism of proteins
Peptide hormone metabolism
SRP-dependent cotranslational protein targeting to membrane
Synthesis, secretion, and deacylation of Ghrelin
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (204)
1 – 10 of 204
SPCS2
Tdark
Family:  Enzyme
Novelty:  0.21358992
p_int:  0.999993059
p_ni:  0.000006941
Score:  0.998
Data Source:  BioPlex,STRINGDB
FUNDC2
Tbio
Novelty:  0.09695817
p_int:  0.999988523
p_ni:  0.000011472
p_wrong:  4e-9
Score:  0.164
Data Source:  BioPlex,STRINGDB
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.999843318
p_ni:  0.000153359
p_wrong:  0.000003323
Score:  0.205
Data Source:  BioPlex,STRINGDB
TOMM22
Tbio
Novelty:  0.01217913
p_int:  0.99975145
p_ni:  0.000246953
p_wrong:  0.000001597
Score:  0.196
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.999605933
p_ni:  0.000394008
p_wrong:  5.9e-8
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.999603809
p_ni:  0.000396175
p_wrong:  1.6e-8
Data Source:  BioPlex
ADAM30
Tdark
Family:  Enzyme
Novelty:  0.25395428
p_int:  0.999602788
p_ni:  0.000397194
p_wrong:  1.8e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
p_int:  0.997889371
p_ni:  0.000931606
p_wrong:  0.001179022
Score:  0.223
Data Source:  BioPlex,STRINGDB
SPCS3
Tbio
Family:  Enzyme
Novelty:  0.13677259
p_int:  0.996961558
p_ni:  0.003038443
Score:  0.998
Data Source:  BioPlex,STRINGDB
APOM
Tbio
Novelty:  0.00505937
p_int:  0.996747856
p_ni:  0.000111016
p_wrong:  0.003141128
Score:  0.188
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.57

PubMed score by year
PubTator Score  1.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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