Tdark SEC11C Signal peptidase complex catalytic subunit SEC11C

Protein Summary

Description

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Uniprot Accession IDs

• Q9BY50
• B2RAA3

Gene Name

• SEC11C

Ensembl ID

• ENST00000587834
• ENSP00000468633
• ENSG00000166562

Symbol

• SEC11L3
• SPC21
• SPCS4C
• SPC21
• SPCS4C
• SEC11L3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
small molecule perturbation	0.84
histone modification site profile	0.81
transcription factor perturbation	0.74
transcription factor	0.67

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Signal Peptidase Complex Catalytic Subunit Sec11c

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Signal Peptidase Complex Catalytic Subunit Sec11c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.27   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.27   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0