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Tbio
CHMP4A
Charged multivesicular body protein 4a

Protein Classes
Protein Summary
Description
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347519
  • ENSP00000324205
  • ENSG00000254505
  • ENST00000609024
  • ENSP00000476412
  • ENST00000645179
  • ENSP00000495781
  • ENSG00000285302
  • ENST00000645308
  • ENSP00000495982

Symbol
  • C14orf123
  • SHAX2
  • SNF7
  • CHMP4
  • SHAX2
  • CHMP4B
  • SNF7-1
  • VPS32A
  • HSPC134
  • VPS32-1
  • C14orf123
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.88
biological process
0.8
tissue sample
0.64
cell type or tissue
0.63
histone modification site profile
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.88   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.88   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
charged multivesicular body protein 4A
VGNC:51481
100051233
Cow
charged multivesicular body protein 4A
VGNC:27302
613647
C. elegans
183288
Species
Name
OMA
EggNOG
Inparanoid
Horse
charged multivesicular body protein 4A
Cow
charged multivesicular body protein 4A
C. elegans
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BY43-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Cellular responses to external stimuli
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Autophagy
Budding and maturation of HIV virion
Cellular responses to external stimuli
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (30)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (111)
1 – 10 of 111
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.989999215
p_ni:  0.009620652
p_wrong:  0.000380133
Data Source:  BioPlex
CDCA3
Tbio
Novelty:  0.05136899
p_int:  0.962372382
p_ni:  0.037627618
Score:  0.218
Data Source:  BioPlex,STRINGDB
ARL6IP6
Tdark
Novelty:  0.36643453
p_int:  0.928729602
p_ni:  0.071255639
p_wrong:  0.000014759
Score:  0.237
Data Source:  BioPlex,STRINGDB
VAX2
Tbio
Family:  TF
Novelty:  0.04763617
p_int:  0.877616758
p_ni:  0.120108002
p_wrong:  0.002275239
Score:  0.54
Data Source:  BioPlex,STRINGDB
NFYA
Tbio
Family:  TF
Novelty:  0.00507094
p_int:  0.750275837
p_ni:  0.24873239
p_wrong:  0.000991773
Score:  0.228
Data Source:  BioPlex,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.998
Data Source:  STRINGDB
CHMP3
Tbio
Novelty:  0.01958573
Score:  0.996
Data Source:  STRINGDB
CHMP7
Tbio
Novelty:  0.12815552
Score:  0.995
Data Source:  STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
Score:  0.993
Data Source:  STRINGDB
PDCD6IP
Tbio
Novelty:  0.01836118
Score:  0.992
Data Source:  STRINGDB
Publication Statistics
PubMed Score  100.88

PubMed score by year
PubTator Score  25.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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