Tbio CHMP4A Charged multivesicular body protein 4a

Protein Summary

Description

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9BY43
• Q14D22
• Q32Q79
• Q86SZ8
• Q96QJ9
• Q9P026

Gene Name

• CHMP4A

Ensembl ID

• ENST00000347519
• ENSP00000324205
• ENSG00000254505
• ENST00000609024
• ENSP00000476412
• ENST00000645179
• ENSP00000495781
• ENSG00000285302
• ENST00000645308
• ENSP00000495982

Symbol

• C14orf123
• SHAX2
• SNF7
• CHMP4
• SHAX2
• CHMP4B
• SNF7-1
• VPS32A
• HSPC134
• VPS32-1
• C14orf123

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.88
biological process	0.8
tissue sample	0.64
cell type or tissue	0.63
histone modification site profile	0.59

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Charged Multivesicular Body Protein 4a

DTO Classes

Protein / Transporter / Charged Multivesicular Body Protein 4a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.56   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.56   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0