Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with trans ...more
- ENST00000373554
- ENSP00000362655
- ENSG00000147099
- ENST00000373556
- ENSP00000362657
- ENST00000373559
- ENSP00000362660
- ENST00000373573
- ENSP00000362674
- ENST00000373589
- ENSP00000362691
- ENST00000439122
- ENSP00000414486
- ENST00000649116
- ENSP00000497925
- HDACL1
- HD8
- WTS
- RPD3
- CDA07
- CDLS5
- KDAC8
- MRXS6
- HDACL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.79 | ||
biological process | 0.76 | ||
kinase perturbation | 0.76 | ||
histone modification site profile | 0.74 | ||
cellular component | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 460.59 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 610 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 460.59 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 610 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 902
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (902)
Protein-Protein Interactions (209)
Nearest Tclin Targets
Pathways (35)
Reactome (26)
KEGG (2)
PathwayCommons (3)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (6)
Components (6)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sodium measurement | 1 | 1 | 1 | 42.2 | |||||
chloride measurement | 1 | 1 | 1 | 33 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sodium measurement | 1 | 42.2 | |||||
chloride measurement | 1 | 33 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | histone deacetylase 8 | 699642 | ||||||
Mouse | MGI:1917565 | 70315 | ||||||
Rat | RGD:1562895 | 363481 | ||||||
Dog | histone deacetylase 8 | VGNC:50631 | 480957 | |||||
Horse | histone deacetylase 8 [Source:HGNC Symbol;Acc:HGNC:13315] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | histone deacetylase 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone deacetylase 8 | |||||
Horse | histone deacetylase 8 [Source:HGNC Symbol;Acc:HGNC:13315] | |||||
Publication Statistics
PubMed Score 460.59
PubMed score by year
PubTator Score 221.98
PubTator score by year
Related Publications
GeneRif Annotations (74)
Items per page:
0 of 0
PMID | Text |
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