Tclin HDAC8 Histone deacetylase 8

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9BY41
• A6ND12
• A6ND61
• A6NET3
• A6NJR3
• A8MQ62
• B4DKN0
• B4DV22
• Q86VC8
• Q9NP76
• Q9NYH4
• HD8

Gene Name

• HDAC8

Ensembl ID

• ENST00000373554
• ENSP00000362655
• ENSG00000147099
• ENST00000373556
• ENSP00000362657
• ENST00000373559
• ENSP00000362660
• ENST00000373573
• ENSP00000362674
• ENST00000373589
• ENSP00000362691
• ENST00000439122
• ENSP00000414486
• ENST00000649116
• ENSP00000497925

Symbol

• HDACL1
• HD8
• WTS
• RPD3
• CDA07
• CDLS5
• KDAC8
• MRXS6
• HDACL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
biological process	0.76
kinase perturbation	0.76
histone modification site profile	0.74
cellular component	0.7

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Histone Deacetylase 8

Protein / Nucleic Acid Binding / Histone Deacetylase 8

Protein / Hydrolase / Deacetylase / Histone Deacetylase 8

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class I / Histone Deacetylase 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.51   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 610   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.51   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 610   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1022

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6