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Tclin
HDAC8
Histone deacetylase 8

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373554
  • ENSP00000362655
  • ENSG00000147099
  • ENST00000373556
  • ENSP00000362657
  • ENST00000373559
  • ENSP00000362660
  • ENST00000373573
  • ENSP00000362674
  • ENST00000373589
  • ENSP00000362691
  • ENST00000439122
  • ENSP00000414486
  • ENST00000649116
  • ENSP00000497925

Symbol
  • HDACL1
  • HD8
  • WTS
  • RPD3
  • CDA07
  • CDLS5
  • KDAC8
  • MRXS6
  • HDACL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
biological process
0.76
kinase perturbation
0.76
histone modification site profile
0.74
cellular component
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 442.2   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 610   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 442.2   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 610   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 641
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (641)
1 – 10 of 641
CHEMBL3622533
chemical structure image
CHEMBL99
chemical structure image
CHEMBL598797
chemical structure image
CHEMBL1631916
chemical structure image
CHEMBL1631918
chemical structure image
CHEMBL1631915
chemical structure image
CHEMBL3670668
chemical structure image
CHEMBL408513
chemical structure image
CHEMBL251011
chemical structure image
CHEMBL1631917
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
histone deacetylase 8
699642
Mouse
MGI:1917565
70315
Rat
RGD:1562895
363481
Dog
histone deacetylase 8
VGNC:50631
480957
Horse
histone deacetylase 8 [Source:HGNC Symbol;Acc:HGNC:13315]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
histone deacetylase 8
Mouse
Rat
Dog
histone deacetylase 8
Horse
histone deacetylase 8 [Source:HGNC Symbol;Acc:HGNC:13315]
Protein Structure (46 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BY41-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 46
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Chromatin modifying enzymes
Chromatin organization
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (209)
1 – 10 of 209
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.985
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.984
Data Source: STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.982
Data Source: STRINGDB
KAT2B
Tchem
Family: Epigenetic
Novelty: 0.00172126
Score: 0.978
Data Source: STRINGDB
KAT2A
Tbio
Family: Epigenetic
Novelty: 0.00238831
Score: 0.978
Data Source: STRINGDB
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
Score: 0.972
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.967
Data Source: STRINGDB
SMG5
Tbio
Novelty: 0.04143189
Score: 0.966
Data Source: STRINGDB
RBBP4
Tbio
Novelty: 0.01062843
Score: 0.965
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  442.20

PubMed score by year
PubTator Score  221.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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