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Tbio
ITPA
Inosine triphosphate pyrophosphatase

Protein Summary
Description
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380113
  • ENSP00000369456
  • ENSG00000125877
  • ENST00000399838
  • ENSP00000382732
  • ENST00000455664
  • ENSP00000413282

Symbol
  • C20orf37
  • My049
  • ITPase
  • NTPase
  • C20orf37
  • dJ794I6.3
  • HLC14-06-P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.96
histone modification site profile
0.68
molecular function
0.67
tissue sample
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.53   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.53   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
16
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inosine triphosphatase
VGNC:6172
746982
Macaque
inosine triphosphatase
717257
Mouse
MGI:96622
16434
Rat
RGD:1589751
311422
Dog
inosine triphosphatase
VGNC:42152
609255
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inosine triphosphatase
Macaque
inosine triphosphatase
Mouse
Rat
Dog
inosine triphosphatase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BY32-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Purine catabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (313)
1 – 10 of 313
LAMTOR5
Tbio
Novelty: 0.003692
p_int: 0.999999905
p_ni: 9.5e-8
Data Source: BioPlex
HHIPL1
Tdark
Novelty: 0.57780473
p_int: 0.998908318
p_ni: 0.001091578
p_wrong: 1.04e-7
Data Source: BioPlex
FAM3B
Tbio
Novelty: 0.00844967
p_int: 0.994094227
p_ni: 0.005905715
p_wrong: 5.9e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
P2RX5
Tchem
Family: IC
Novelty: 0.01591178
p_int: 0.993821766
p_ni: 0.005404968
p_wrong: 0.000773265
Data Source: BioPlex
VPS4B
Tbio
Novelty: 0.00788708
p_int: 0.992453479
p_ni: 0.007545936
p_wrong: 5.85e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
HTR2C
Tclin
Family: GPCR
Novelty: 0.00074287
p_int: 0.990131557
p_ni: 0.006731233
p_wrong: 0.00313721
Data Source: BioPlex
CCL22
Tbio
Novelty: 0.00245992
p_int: 0.98866779
p_ni: 0.009061978
p_wrong: 0.002270232
Data Source: BioPlex
PPM1L
Tbio
Family: Enzyme
Novelty: 0.09146774
p_int: 0.982355557
p_ni: 0.016183399
p_wrong: 0.001461045
Data Source: BioPlex
FGB
Tbio
Novelty: 0.00437751
p_int: 0.979913621
p_ni: 0.019622064
p_wrong: 0.000464314
Score: 0.183
Data Source: BioPlex,STRINGDB
TOR1AIP2
Tbio
Novelty: 0.08912351
p_int: 0.979218567
p_ni: 0.018441927
p_wrong: 0.002339506
Data Source: BioPlex
Publication Statistics
PubMed Score  407.53

PubMed score by year
PubTator Score  246.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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