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Tbio
ADGRE3
Adhesion G protein-coupled receptor E3

Protein Summary
Description
Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils. This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253673
  • ENSP00000253673
  • ENSG00000131355
  • ENST00000344373
  • ENSP00000340758

Symbol
  • EMR3
  • EMR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
tissue
0.66
cell line
0.59
tissue sample
0.52
trait
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.69   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.69   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (16)
1 – 10 of 16
MUC5AC
Tbio
Novelty: 0.00053768
Score: 0.64
Data Source: STRINGDB
CD55
Tbio
Novelty: 0.00064328
Score: 0.624
Data Source: STRINGDB
CRISP2
Tbio
Novelty: 0.02158087
Score: 0.581
Data Source: STRINGDB
C19orf67
Tdark
Score: 0.51
Data Source: STRINGDB
CRISP3
Tbio
Novelty: 0.02250295
Score: 0.494
Data Source: STRINGDB
PILRA
Tbio
Novelty: 0.07858669
Score: 0.459
Data Source: STRINGDB
TLR6
Tbio
Novelty: 0.00137513
Score: 0.445
Data Source: STRINGDB
DDX19A
Tdark
Family: Enzyme
Novelty: 1.09090909
Score: 0.445
Data Source: STRINGDB
PODNL1
Tdark
Novelty: 3.4375
Score: 0.443
Data Source: STRINGDB
SEMG2
Tbio
Novelty: 0.10545717
Score: 0.437
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.69

PubMed score by year
PubTator Score  8.18

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer