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Tbio
SLC4A5
Electrogenic sodium bicarbonate cotransporter 4

Protein Summary
Description
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346834
  • ENSP00000251768
  • ENSG00000188687
  • ENST00000358683
  • ENSP00000351513
  • ENST00000377632
  • ENSP00000366859
  • ENST00000377634
  • ENSP00000366861
  • ENST00000394019
  • ENSP00000377587
  • ENST00000423644
  • ENSP00000395804

Symbol
  • NBC4
  • NBC4
  • NBCe2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
molecular function
0.81
protein domain
0.73
microRNA
0.62
gene perturbation
0.61


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.47   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.47   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
2
45.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
45.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443220
232156
Rat
RGD:1303009
297386
Dog
solute carrier family 4 member 5
VGNC:46435
612275
Horse
solute carrier family 4 member 5
VGNC:23235
100069223
Cow
solute carrier family 4 member 5
VGNC:34895
100297538
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
solute carrier family 4 member 5
Horse
solute carrier family 4 member 5
Cow
solute carrier family 4 member 5
Pathways (5)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (37)
1 – 10 of 37
ALMS1
Tbio
Novelty: 0.00694228
Score: 0.8
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.761
Data Source: STRINGDB
NPHS2
Tbio
Novelty: 0.00212981
Score: 0.633
Data Source: STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
Score: 0.628
Data Source: STRINGDB
SLC35B4
Tbio
Family: Transporter
Novelty: 0.06873345
Score: 0.58
Data Source: STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
Score: 0.552
Data Source: STRINGDB
SLC16A4
Tbio
Family: Transporter
Novelty: 0.0042395
Score: 0.551
Data Source: STRINGDB
PTS
Tbio
Family: Enzyme
Novelty: 0.00279396
Score: 0.531
Data Source: STRINGDB
UNC5CL
Tbio
Novelty: 0.11511991
Score: 0.53
Data Source: STRINGDB
OSGEP
Tbio
Family: Enzyme
Novelty: 0.0106198
Score: 0.505
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.47

PubMed score by year
PubTator Score  25.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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