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Tbio
RSPO3
R-spondin-3

Protein Summary
Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356698
  • ENSP00000349131
  • ENSG00000146374
  • ENST00000368317
  • ENSP00000357300

Symbol
  • PWTSR
  • THSD2
  • PWTSR
  • THSD2
  • CRISTIN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.61
protein domain
0.58
disease
0.57
virus perturbation
0.55
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.26   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.26   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (67)
1 – 10 of 67
DPY19L3
Tbio
Family:  Enzyme
Novelty:  0.35244121
p_int:  0.999990664
p_ni:  0.000009324
p_wrong:  1.2e-8
Score:  0.551
Data Source:  BioPlex,STRINGDB
LGR4
Tbio
Family:  GPCR
Novelty:  0.01180123
Score:  0.987
Data Source:  Reactome,STRINGDB
ZNRF3
Tbio
Family:  Enzyme
Novelty:  0.03351825
Score:  0.984
Data Source:  Reactome,STRINGDB
LGR5
Tbio
Family:  GPCR
Novelty:  0.00105035
Score:  0.972
Data Source:  Reactome,STRINGDB
RNF43
Tbio
Family:  Enzyme
Novelty:  0.01258908
Score:  0.971
Data Source:  Reactome,STRINGDB
LGR6
Tbio
Family:  GPCR
Novelty:  0.02186397
Score:  0.969
Data Source:  Reactome,STRINGDB
RSPO2
Tbio
Novelty:  0.0188211
Score:  0.912
Data Source:  STRINGDB
RSPO4
Tbio
Novelty:  0.05670413
Score:  0.909
Data Source:  STRINGDB
RSPO1
Tbio
Novelty:  0.00365075
Score:  0.908
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.904
Data Source:  STRINGDB
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in WNT signaling
Reactome
Regulation of FZD by ubiquitination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Regulation of FZD by ubiquitination
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
18
22
56
99.9
waist-hip ratio
7
18
26
99.8
heel bone mineral density
3
10
16
99.7
BMI-adjusted waist circumference
7
19
25
99.6
hip circumference
2
16
21
99.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
56
99.9
waist-hip ratio
26
99.8
heel bone mineral density
16
99.7
BMI-adjusted waist circumference
25
99.6
hip circumference
21
99.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
R-spondin 3
VGNC:11220
745364
Macaque
R-spondin 3
712288
Mouse
MGI:1920030
72780
Rat
RGD:1563246
498997
Dog
R-spondin 3
VGNC:49764
476287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
R-spondin 3
Macaque
R-spondin 3
Mouse
Rat
Dog
R-spondin 3
Publication Statistics
PubMed Score 52.26
PubMed score by year
PubTator Score 25.15
PubTator score by year