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Tbio
MAP1LC3C
Microtubule-associated proteins 1A/1B light chain 3C

Protein Summary
Description
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643). Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357246
  • ENSP00000349785
  • ENSG00000197769

Symbol
  • LC3C
  • ATG8J
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.65
tissue sample
0.59
tissue
0.52
cell type or tissue
0.41
protein domain
0.41


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.54   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.54   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1 light chain 3 gamma
VGNC:8072
457857
Dog
microtubule associated protein 1 light chain 3 gamma
VGNC:42957
611659
Cow
microtubule associated protein 1 light chain 3 gamma
VGNC:31180
507432
Opossum
microtubule associated protein 1 light chain 3 gamma
100027672
Chicken
microtubule associated protein 1 light chain 3 gamma
CGNC:8165
421504
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 1 light chain 3 gamma
Dog
microtubule associated protein 1 light chain 3 gamma
Cow
microtubule associated protein 1 light chain 3 gamma
Opossum
microtubule associated protein 1 light chain 3 gamma
Chicken
microtubule associated protein 1 light chain 3 gamma
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BXW4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (114)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (83)
1 – 10 of 83
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.940948504
p_ni:  0.059051496
Score:  0.32
Data Source:  BioPlex,STRINGDB
ATG4B
Tchem
Family:  Enzyme
Novelty:  0.0088416
Score:  0.989
Data Source:  STRINGDB
ATG3
Tbio
Novelty:  0.00541077
Score:  0.989
Data Source:  STRINGDB
ATG7
Tchem
Novelty:  0.00120728
Score:  0.989
Data Source:  STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.979
Data Source:  STRINGDB
ATG12
Tbio
Novelty:  0.00304298
Score:  0.974
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.973
Data Source:  STRINGDB
WIPI2
Tbio
Novelty:  0.02685992
Score:  0.972
Data Source:  STRINGDB
ATG4A
Tbio
Family:  Enzyme
Novelty:  0.04073485
Score:  0.967
Data Source:  STRINGDB
ATG4D
Tbio
Family:  Enzyme
Novelty:  0.07285957
Score:  0.966
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.54

PubMed score by year
PubTator Score  8.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer