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Tbio
USP26
Ubiquitin carboxyl-terminal hydrolase 26

Protein Summary
Description
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370832
  • ENSP00000359869
  • ENSG00000134588
  • ENST00000511190
  • ENSP00000423390
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
tissue
0.61
cell line
0.53
phenotype
0.48
metabolite
0.45


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.29   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.29   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 26
VGNC:1191
100611877
Mouse
MGI:1933247
83563
Rat
RGD:1563443
302488
Dog
ubiquitin specific peptidase 26
VGNC:48185
492143
Horse
ubiquitin specific peptidase 26
VGNC:24837
100057231
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 26
Mouse
Rat
Dog
ubiquitin specific peptidase 26
Horse
ubiquitin specific peptidase 26
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BXU7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Protein-Protein Interactions (56)
1 – 10 of 56
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.959
Data Source:  Reactome,STRINGDB
WDR20
Tbio
Novelty:  0.03031804
Score:  0.947
Data Source:  STRINGDB
WDR48
Tbio
Novelty:  0.04070481
Score:  0.945
Data Source:  STRINGDB
USP12
Tbio
Family:  Enzyme
Novelty:  0.0460009
Score:  0.927
Data Source:  STRINGDB
SPATA3
Tdark
Novelty:  0.19208899
Score:  0.676
Data Source:  STRINGDB
TNP1
Tbio
Novelty:  0.01264731
Score:  0.629
Data Source:  STRINGDB
TEX11
Tbio
Novelty:  0.04868648
Score:  0.612
Data Source:  STRINGDB
TNP2
Tbio
Novelty:  0.01170636
Score:  0.591
Data Source:  STRINGDB
USP38
Tbio
Family:  Enzyme
Novelty:  0.10350208
Score:  0.589
Data Source:  STRINGDB
USP44
Tbio
Family:  Enzyme
Novelty:  0.0550805
Score:  0.587
Data Source:  STRINGDB
Publication Statistics
PubMed Score  38.29

PubMed score by year
PubTator Score  32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer