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Tchem
STK31
Serine/threonine-protein kinase 31

Protein Summary
Description
This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354639
  • ENSP00000346660
  • ENSG00000196335
  • ENST00000355870
  • ENSP00000348132
  • ENST00000433467
  • ENSP00000411852

Symbol
  • SGK396
  • TDRD8
  • SGK396
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
gene perturbation
0.83
cell type or tissue
0.65
tissue sample
0.62
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.11   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.11   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (46)
TDRD9
Tbio
Family:  Epigenetic
Novelty:  0.10913126
Score:  0.791
Data Source:  STRINGDB
TDRD5
Tdark
Family:  Epigenetic
Novelty:  0.115495
Score:  0.764
Data Source:  STRINGDB
TDRD15
Tdark
Family:  Epigenetic
Novelty:  0.68139902
Score:  0.734
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.721
Data Source:  STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.718
Data Source:  STRINGDB
TDRKH
Tbio
Family:  Epigenetic
Novelty:  0.0875409
Score:  0.695
Data Source:  STRINGDB
TDRD10
Tdark
Family:  Epigenetic
Novelty:  0.59172141
Score:  0.693
Data Source:  STRINGDB
TBRG4
Tbio
Novelty:  0.03556613
Score:  0.691
Data Source:  STRINGDB
DCLK3
Tchem
Family:  Kinase
Novelty:  0.00454456
Score:  0.691
Data Source:  STRINGDB
SRMS
Tchem
Family:  Kinase
Novelty:  0.22151736
Score:  0.686
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
5.7
24.5
mathematical ability
1
1
1
17.8
1
1
1
10.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
5.7
24.5
mathematical ability
1
17.8
1
10.1
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 31
VGNC:4522
472316
Macaque
serine/threonine kinase 31
703886
Mouse
MGI:1924735
77485
Rat
RGD:1564384
500120
Dog
serine/threonine kinase 31
VGNC:46912
475256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 31
Macaque
serine/threonine kinase 31
Mouse
Rat
Dog
serine/threonine kinase 31
Publication Statistics
PubMed Score 11.11
PubMed score by year
PubTator Score 8.14
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title