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Tbio
RNF17
RING finger protein 17

Protein Classes
Protein Summary
Description
Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255324
  • ENSP00000255324
  • ENSG00000132972
  • ENST00000255325
  • ENSP00000255325

Symbol
  • TDRD4
  • TDRD4
  • Mmip-2
  • SPATA23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.75
virus perturbation
0.68
transcription factor perturbation
0.61
protein domain
0.58
kinase perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
46.9
cystic fibrosis associated meconium ileus
1
1
0
1.6
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
46.9
cystic fibrosis associated meconium ileus
0
1.6
39.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 17
VGNC:5103
467234
Mouse
MGI:1353419
30054
Rat
RGD:1310486
305908
Dog
ring finger protein 17
VGNC:45645
486056
Horse
ring finger protein 17
VGNC:22453
100053012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 17
Mouse
Rat
Dog
ring finger protein 17
Horse
ring finger protein 17
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BXT8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (66)
1 – 10 of 66
PIWIL2
Tbio
Novelty:  0.00907402
Score:  0.874
Data Source:  STRINGDB
PIWIL1
Tbio
Novelty:  0.00095911
Score:  0.843
Data Source:  STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.819
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.787
Data Source:  STRINGDB
MOV10L1
Tbio
Family:  Enzyme
Novelty:  0.09735465
Score:  0.734
Data Source:  STRINGDB
STOML1
Tbio
Novelty:  0.05746576
Score:  0.731
Data Source:  STRINGDB
PIWIL3
Tbio
Novelty:  0.08705179
Score:  0.717
Data Source:  STRINGDB
UGGT2
Tbio
Family:  Enzyme
Novelty:  0.20635638
Score:  0.715
Data Source:  STRINGDB
TMEM94
Tdark
Novelty:  0.39746809
Score:  0.702
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.671
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.51

PubMed score by year
PubTator Score  6.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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