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Tdark
CACNG6
Voltage-dependent calcium channel gamma-6 subunit

Protein Summary
Description
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252729
  • ENSP00000252729
  • ENSG00000130433
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
cell line
0.47
metabolite
0.45
PubMedID
0.44
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
CACNG7
Tdark
Family:  IC
Novelty:  0.32460059
Score:  0.949
Data Source:  STRINGDB
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
Score:  0.938
Data Source:  STRINGDB
CACNG3
Tbio
Family:  IC
Novelty:  0.32654561
Score:  0.931
Data Source:  STRINGDB
CACNG8
Tbio
Family:  IC
Novelty:  0.26770379
Score:  0.909
Data Source:  STRINGDB
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
Score:  0.909
Data Source:  STRINGDB
CACNB4
Tbio
Family:  IC
Novelty:  0.01564026
Score:  0.909
Data Source:  STRINGDB
CACNA1S
Tclin
Family:  IC
Novelty:  0.00434282
Score:  0.905
Data Source:  STRINGDB
CACNA1D
Tclin
Family:  IC
Novelty:  0.00314752
Score:  0.903
Data Source:  STRINGDB
CACNA1C
Tclin
Family:  IC
Novelty:  0.00099998
Score:  0.902
Data Source:  STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
Score:  0.902
Data Source:  STRINGDB
Pathways (14)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
68.6
blood protein measurement
1
1
1
54
phosphatidylinositol measurement
2
1
2
45.9
educational attainment
1
1
1
30.9
cognitive function measurement
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
68.6
blood protein measurement
1
54
phosphatidylinositol measurement
2
45.9
educational attainment
1
30.9
cognitive function measurement
1
21.6
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 6
VGNC:7470
749208
Macaque
calcium voltage-gated channel auxiliary subunit gamma 6
720548
Mouse
MGI:1859168
54378
Rat
RGD:628806
140727
Dog
calcium voltage-gated channel auxiliary subunit gamma 6
VGNC:38651
484315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 6
Macaque
calcium voltage-gated channel auxiliary subunit gamma 6
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 6
Publication Statistics
PubMed Score 1.05
PubMed score by year
PubTator Score 1.42
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title