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Tbio
AP1M1
AP-1 complex subunit mu-1

Protein Summary
Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291439
  • ENSP00000291439
  • ENSG00000072958
  • ENST00000444449
  • ENSP00000388996

Symbol
  • CLTNM
  • AP47
  • CLTNM
  • MU-1A
  • CLAPM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
cellular component
0.89
transcription factor binding site profile
0.86
protein domain
0.85
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.07   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.07   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
4.7
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
Golgi Associated Vesicle Biogenesis
HIV Infection
Host Interactions of HIV factors
Gene Ontology Terms (17)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (250)
1 – 10 of 250
AP1S2
Tbio
Novelty: 0.01413503
p_int: 0.999999324
p_ni: 6.76e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MEA1
Tbio
Novelty: 0.04292367
p_int: 0.999997166
p_ni: 0.000002835
Score: 0.188
Data Source: BioPlex,STRINGDB
AP1S3
Tbio
Novelty: 0.14425094
p_int: 0.999983873
p_ni: 0.000016127
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
FBXO4
Tbio
Novelty: 0.06891705
p_int: 0.879720504
p_ni: 0.120279496
Score: 0.214
Data Source: BioPlex,STRINGDB
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
p_int: 0.874359977
p_ni: 0.125640023
Data Source: BioPlex
TGOLN2
Tbio
Novelty: 0.005107
p_int: 0.8734645
p_ni: 0.1265355
Score: 0.948
Data Source: BioPlex,STRINGDB
CPD
Tbio
Family: Enzyme
Novelty: 0.02105758
p_int: 0.846661469
p_ni: 0.153338531
Score: 0.946
Data Source: BioPlex,STRINGDB
IFNLR1
Tbio
Novelty: 0.01990628
p_int: 0.819771149
p_ni: 0.180228851
Data Source: BioPlex
TLR2
Tchem
Novelty: 0.00023242
p_int: 0.762342178
p_ni: 0.237657822
Score: 0.239
Data Source: BioPlex,STRINGDB
AP1G1
Tbio
Novelty: 0.03754132
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  29.07

PubMed score by year
PubTator Score  6.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer