Tbio IDI2 Isopentenyl-diphosphate delta-isomerase 2

Protein Summary

Description

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9BXS1

Gene Name

• IDI2

Ensembl ID

• ENST00000277517
• ENSP00000277517
• ENSG00000148377

Symbol

• IPPI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.76
cell line	0.54
tissue sample	0.5
virus perturbation	0.5
pathway	0.49

Protein Classes

PANTHER Classes

Protein / Isomerase / Isopentenyl-diphosphate Delta-isomerase 2

DTO Classes

Protein / Enzyme / Isomerase / Isopentenyl-diphosphate Delta-isomerase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.7   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.7   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

SSBP3

Tbio

Novelty:  0.01955714

p_int:  0.999999884

p_ni:  1.16e-7

Score:  0.86

Data Source:  BioPlex,STRINGDB

LDB1

Tbio

Novelty:  0.01110112

p_int:  0.99999943

p_ni:  5.69e-7

Score:  0.832

Data Source:  BioPlex,STRINGDB

SSBP2

Tbio

Novelty:  0.06546999

p_int:  0.999998707

p_ni:  0.000001292

p_wrong:  1e-9

Score:  0.867

Data Source:  BioPlex,STRINGDB

SSBP4

Tdark

Novelty:  0.27365687

p_int:  0.999997226

p_ni:  0.000002773

p_wrong:  1e-9

Score:  0.873

Data Source:  BioPlex,STRINGDB

LMO4

Tbio

Novelty:  0.08806373

p_int:  0.99998866

p_ni:  7.43e-7

p_wrong:  0.000010597

Score:  0.86

Data Source:  BioPlex,STRINGDB

FAM76B

Tdark

Novelty:  0.80316253

p_int:  0.999848539

p_ni:  0.000151461

Score:  0.345

Data Source:  BioPlex,STRINGDB

ISL2

Tbio

Family:  TF

Novelty:  0.03917372

p_int:  0.996997367

p_ni:  0.00294532

p_wrong:  0.000057313

Score:  0.867

Data Source:  BioPlex,STRINGDB

RABL2B

Tdark

Family:  Enzyme

Novelty:  0.16730643

p_int:  0.99531165

p_ni:  0.00459404

p_wrong:  0.00009431

Score:  0.295

Data Source:  BioPlex,STRINGDB

RNF114

Tbio

Family:  Enzyme

Novelty:  0.06758257

p_int:  0.99531165

p_ni:  0.00459404

p_wrong:  0.00009431

Score:  0.187

Data Source:  BioPlex,STRINGDB

LMX1B

Tbio

Family:  TF

Novelty:  0.00405645

p_int:  0.851854908

p_ni:  0.007234636

p_wrong:  0.140910457

Score:  0.806

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (1)

1 – 1 of 1

FDPS

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Terpenoid backbone biosynthesis

Pathways (13)

Reactome (4)

KEGG (2)

PathwayCommons (6)

UniProt (1)

Cholesterol biosynthesis (R-HSA-191273)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cholesterol biosynthesis	25 targets	R-HSA-191273
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of steroids	151 targets	R-HSA-8957322

Name	Explore in Pharos	Explore in Source
Cholesterol biosynthesis	25 targets	R-HSA-191273
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of steroids	151 targets	R-HSA-8957322

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (2)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
isopentenyl-diphosphate delta-isomerase activity	Inferred from Direct Assay (IDA)	UniProtKB
hydrolase activity	Inferred from Electronic Annotation (IEA)	InterPro
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3	3	3		93.7
creatinine measurement	EFO_0004518	3	2	3		90.7
glomerular filtration rate	EFO_0005208	3	2	3		90.6
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		83.2
neutrophil percentage of granulocytes	EFO_0007994	1	1	1		72.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3		93.7
creatinine measurement	EFO_0004518	3		90.7
glomerular filtration rate	EFO_0005208	3		90.6
eosinophil percentage of leukocytes	EFO_0007991	2		83.2
neutrophil percentage of granulocytes	EFO_0007994	1		72.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Isomerase
Isoprene biosynthesis
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding

GWAS Trait Find Similar Targets

No Header	No Header
creatinine measurement
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
glomerular filtration rate
neutrophil percentage of granulocytes
serum urea measurement
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	isopentenyl-diphosphate delta isomerase 2	MGI:2444315	320581
Mouse	predicted gene 9745	MGI:3704398	100039655
Rat	similar to isopentenyl diphosphate delta-isomerase type 2	RGD:1564347	364764
Opossum	isopentenyl-diphosphate Delta-isomerase 1-like		100021550
C. elegans	Isopentenyl Diphosphate Isomerase		176142

Species	Name	OMA	EggNOG	Inparanoid
Mouse	isopentenyl-diphosphate delta isomerase 2
Mouse	predicted gene 9745
Rat	similar to isopentenyl diphosphate delta-isomerase type 2
Opossum	isopentenyl-diphosphate Delta-isomerase 1-like
C. elegans	Isopentenyl Diphosphate Isomerase

Publication Statistics

PubMed Score 40.70

PubMed score by year

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PubTator Score 12.00

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title