Tbio IDI2 Isopentenyl-diphosphate delta-isomerase 2

Protein Classes

PANTHER Classes

Protein / Isomerase / Isopentenyl-diphosphate Delta-isomerase 2

DTO Classes

Protein / Enzyme / Isomerase / Isopentenyl-diphosphate Delta-isomerase 2

Protein Summary

Description

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9BXS1

Gene Name

• IDI2

Ensembl ID

• ENST00000277517
• ENSP00000277517
• ENSG00000148377

Symbol

• IPPI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.76
cell line	0.54
tissue sample	0.5
virus perturbation	0.5
pathway	0.49

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.65   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.65   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (13)

Reactome (4)

KEGG (2)

PathwayCommons (6)

UniProt (1)

Cholesterol biosynthesis (R-HSA-191273)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cholesterol biosynthesis	25 targets	R-HSA-191273
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of steroids	151 targets	R-HSA-8957322

Name	Explore in Pharos	Explore in Source
Cholesterol biosynthesis	25 targets	R-HSA-191273
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of steroids	151 targets	R-HSA-8957322

Gene Ontology Terms (10)

Functions (3)

Components (2)

Processes (5)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
isopentenyl-diphosphate delta-isomerase activity	Inferred from Direct Assay (IDA)	UniProtKB
hydrolase activity	Inferred from Electronic Annotation (IEA)	InterPro
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

SSBP3

Tbio

Novelty: 0.02698795

p_int: 0.999999884

p_ni: 1.16e-7

Score: 0.86

Data Source: BioPlex,STRINGDB

LDB1

Tbio

Novelty: 0.00548345

p_int: 0.99999943

p_ni: 5.69e-7

Score: 0.832

Data Source: BioPlex,STRINGDB

SSBP2

Tbio

Novelty: 0.07797045

p_int: 0.999998707

p_ni: 0.000001292

p_wrong: 1e-9

Score: 0.867

Data Source: BioPlex,STRINGDB

SSBP4

Tdark

Novelty: 0.54545455

p_int: 0.999997226

p_ni: 0.000002773

p_wrong: 1e-9

Score: 0.873

Data Source: BioPlex,STRINGDB

LMO4

Tbio

Novelty: 0.08518694

p_int: 0.99998866

p_ni: 7.43e-7

p_wrong: 0.000010597

Score: 0.86

Data Source: BioPlex,STRINGDB

FAM76B

Tdark

Novelty: 1

p_int: 0.999848539

p_ni: 0.000151461

Score: 0.345

Data Source: BioPlex,STRINGDB

ISL2

Tbio

Family: TF

Novelty: 0.03469276

p_int: 0.996997367

p_ni: 0.00294532

p_wrong: 0.000057313

Score: 0.867

Data Source: BioPlex,STRINGDB

RABL2B

Tdark

Family: Enzyme

Novelty: 0.23346304

p_int: 0.99531165

p_ni: 0.00459404

p_wrong: 0.00009431

Score: 0.295

Data Source: BioPlex,STRINGDB

RNF114

Tbio

Family: Enzyme

Novelty: 0.07098319

p_int: 0.99531165

p_ni: 0.00459404

p_wrong: 0.00009431

Score: 0.187

Data Source: BioPlex,STRINGDB

LMX1B

Tbio

Family: TF

Novelty: 0.00535467

p_int: 0.851854908

p_ni: 0.007234636

p_wrong: 0.140910457

Score: 0.806

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  23.65

PubMed score by year

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PubTator Score  12

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFNTKNRILIQQR

1-70

SDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPGEQISPEDIVFMTIYHHKAKS

70-140

DRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELWELLEREARGEVKVTPWLRTIAERFLYRWWP

140-210

HLDDVTPFVELHKIHRV

210-227

MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFNTKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPGEQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELWELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV

Find similar targets by:

Uniprot Keyword

3D-structure
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Isomerase
Isoprene biosynthesis
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding