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Tbio
CFHR5
Complement factor H-related protein 5

Protein Summary
Description
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256785
  • ENSP00000256785
  • ENSG00000134389

Symbol
  • CFHL5
  • FHR5
  • FHR5
  • CFHL5
  • FHR-5
  • CFHR5D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.6
disease
0.52
microRNA
0.5
cell line
0.45
biological term
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.7   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.7   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.7
87.8
response to phenytoin
1
1
0
7
46.9
maculopapular eruption
1
1
0
7
46.9
blood protein measurement
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
87.8
response to phenytoin
0
7
46.9
maculopapular eruption
0
7
46.9
blood protein measurement
1
5.7
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement factor H related 5
VGNC:6735
457605
Dog
complement factor H related 5
490262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement factor H related 5
Dog
complement factor H related 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BXR6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Protein-Protein Interactions (35)
1 – 10 of 35
C3
Tclin
Novelty:  0.00019115
Score:  0.987
Data Source:  Reactome,STRINGDB
CFI
Tbio
Novelty:  0.00271423
Score:  0.679
Data Source:  STRINGDB
CD46
Tbio
Novelty:  0.00098341
Score:  0.669
Data Source:  STRINGDB
CFB
Tchem
Novelty:  0.00102672
Score:  0.668
Data Source:  STRINGDB
MYBPH
Tbio
Novelty:  0.00247863
Score:  0.641
Data Source:  STRINGDB
PTX3
Tbio
Novelty:  0.00153752
Score:  0.61
Data Source:  STRINGDB
RAPGEF1
Tbio
Novelty:  0.00365765
Score:  0.589
Data Source:  STRINGDB
DGKE
Tbio
Family:  Enzyme
Novelty:  0.01881016
Score:  0.581
Data Source:  STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
Score:  0.565
Data Source:  STRINGDB
C8A
Tbio
Novelty:  0.00429321
Score:  0.562
Data Source:  STRINGDB
Publication Statistics
PubMed Score  58.70

PubMed score by year
PubTator Score  41.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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