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Tbio
TLR10
Toll-like receptor 10

Protein Summary
Description
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308973
  • ENSP00000308925
  • ENSG00000174123
  • ENST00000361424
  • ENSP00000354459
  • ENST00000506111
  • ENSP00000421483
  • ENST00000508334
  • ENSP00000424923
  • ENST00000613579
  • ENSP00000478206
  • ENST00000622002
  • ENSP00000478985

Symbol
  • CD290
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
protein domain
0.73
tissue sample
0.63
phenotype
0.6
biological term
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.65   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.65   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (281)
ECEL1
Tbio
Family:  Enzyme
Novelty:  0.01488521
p_int:  0.999993746
p_ni:  0.000006254
Data Source:  BioPlex
FBXO45
Tbio
Novelty:  0.05784607
p_int:  0.999127098
p_ni:  0.000591436
p_wrong:  0.000281467
Data Source:  BioPlex
PIPSL
Tdark
p_int:  0.99705852
p_ni:  0.002941479
p_wrong:  1e-9
Data Source:  BioPlex
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.993260893
p_ni:  0.006739107
Score:  0.392
Data Source:  BioPlex,STRINGDB
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.977772383
p_ni:  0.021510197
p_wrong:  0.00071742
Data Source:  BioPlex
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
p_int:  0.966838208
p_ni:  0.033161792
Data Source:  BioPlex
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.964233734
p_ni:  0.035766265
p_wrong:  1e-9
Data Source:  BioPlex
TMEM223
Tdark
Novelty:  0.89146194
p_int:  0.926842851
p_ni:  0.0668395
p_wrong:  0.006317649
Data Source:  BioPlex
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.871592562
p_ni:  0.127913315
p_wrong:  0.000494124
Data Source:  BioPlex
UPK3BL1
Tdark
Novelty:  5
p_int:  0.815280746
p_ni:  0.184547617
p_wrong:  0.000171639
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (106)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with the TLR signaling cascade
Reactome
Diseases of Immune System
Reactome
IRAK4 deficiency (TLR5)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with the TLR signaling cascade
Diseases of Immune System
IRAK4 deficiency (TLR5)
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
11
8
1
1.1
99.3
allergic disease
7
8
3
1.1
99.2
4
4
0
1.1
97.3
age at onset
2
2
1
1.1
93.6
childhood onset asthma
2
1
0
1.2
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
1
1.1
99.3
allergic disease
3
1.1
99.2
0
1.1
97.3
age at onset
1
1.1
93.6
childhood onset asthma
0
1.2
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 10
VGNC:12858
461166
Macaque
toll like receptor 10
697980
Dog
toll like receptor 10
VGNC:53248
100379585
Horse
toll like receptor 10
VGNC:49319
100064614
Cow
toll like receptor 10
VGNC:50019
539791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 10
Macaque
toll like receptor 10
Dog
toll like receptor 10
Horse
toll like receptor 10
Cow
toll like receptor 10
Publication Statistics
PubMed Score 188.65
PubMed score by year
PubTator Score 75.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title