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Tbio
QTRT1
Queuine tRNA-ribosyltransferase catalytic subunit 1

Protein Summary
Description
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250237
  • ENSP00000250237
  • ENSG00000213339
  • ENST00000421333
  • ENSP00000389126

Symbol
  • TGT
  • TGUT
  • TGT
  • TGUT
  • FP3235
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
transcription factor binding site profile
0.74
tissue sample
0.7
gene perturbation
0.68
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
77
forced expiratory volume
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
77
forced expiratory volume
1
30.9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Protein-Protein Interactions (106)
1 – 10 of 106
THUMPD1
Tdark
Novelty: 0.19420931
p_int: 0.999998026
p_ni: 0.000001918
p_wrong: 5.6e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
NOG
Tbio
Novelty: 0.0010373
p_int: 0.999903192
p_ni: 0.000027801
p_wrong: 0.000069007
Data Source: BioPlex
APBB2
Tbio
Novelty: 0.06546724
p_int: 0.999791913
p_ni: 0.000208065
p_wrong: 2.2e-8
Score: 0.555
Data Source: BioPlex,STRINGDB
PRAME
Tbio
Novelty: 0.00543263
p_int: 0.986839625
p_ni: 0.012360019
p_wrong: 0.000800355
Score: 0.19
Data Source: BioPlex,STRINGDB
APBB1
Tbio
Novelty: 0.00630564
p_int: 0.985128024
p_ni: 0.01487197
p_wrong: 6e-9
Score: 0.748
Data Source: BioPlex,STRINGDB
PLS1
Tbio
Novelty: 0.00538817
p_int: 0.982524597
p_ni: 0.0174754
p_wrong: 4e-9
Data Source: BioPlex
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.93192891
p_ni: 0.06807109
Score: 0.18
Data Source: BioPlex,STRINGDB
CLEC11A
Tbio
Novelty: 0.03060601
p_int: 0.915388798
p_ni: 0.000043943
p_wrong: 0.084567259
Data Source: BioPlex
POLE4
Tdark
Family: Enzyme
Novelty: 0.23346084
p_int: 0.760265428
p_ni: 0.239249016
p_wrong: 0.000485556
Score: 0.53
Data Source: BioPlex,STRINGDB
APP
Tchem
Novelty: 0.00008964
p_int: 0.753174959
p_ni: 0.24682504
Score: 0.489
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  21.39

PubMed score by year
PubTator Score  138.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer