Tbio PAPPA2 Pappalysin-2

Protein Summary

Description

Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9BXP8
• A9Z1Y8
• Q96PH7
• Q96PH8
• Q9H4C9

Gene Name

• PAPPA2

Ensembl ID

• ENST00000367661
• ENSP00000356633
• ENSG00000116183
• ENST00000367662
• ENSP00000356634

Symbol

• PLAC3
• PAPPE
• PLAC3
• PAPP-E
• PAPP-A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
microRNA	0.9
cell type or tissue	0.79
phenotype	0.62
small molecule perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.54   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.54   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0