Tbio SRRT Serrate RNA effector molecule homolog

Protein Summary

Description

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Uniprot Accession IDs

• Q9BXP5
• A4D2E5
• A4D2E6
• A6NK22
• B4DJL4
• B4DZA6
• O95808
• Q32MI4
• Q6NT74
• Q8TDQ5
• Q9BWP6
• Q9BXP4
• Q9Y4S4

Gene Name

• SRRT

Ensembl ID

• ENST00000611405
• ENSP00000480421
• ENSG00000087087
• ENST00000614484
• ENSP00000481173
• ENST00000618262
• ENSP00000478341
• ENST00000618411
• ENSP00000483556

Symbol

• ARS2
• ASR2
• ARS2
• ASR2
• serrate

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
interacting protein	0.94
transcription factor binding site profile	0.92
virus perturbation	0.92
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.13   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.13   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0