Tbio CLEC7A C-type lectin domain family 7 member A

Protein Summary

Description

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BXN2
• B2R861
• B7Z494
• B7Z5A9
• B7Z5B9
• Q6IPS7
• Q96D32
• Q96DR9
• Q96LD3
• Q96PA4
• Q96PA5
• Q96PA6
• Q96PA7
• Q96PA8
• Q9H1K3

Gene Name

• CLEC7A

Ensembl ID

• ENST00000298523
• ENSP00000298523
• ENSG00000172243
• ENST00000304084
• ENSP00000302569
• ENST00000310002
• ENSP00000312089
• ENST00000349926
• ENSP00000344723
• ENST00000353231
• ENSP00000266456
• ENST00000396484
• ENSP00000379743
• ENST00000465100
• ENSP00000436923
• ENST00000529761
• ENSP00000432876
• ENST00000531192
• ENSP00000434392
• ENST00000533022
• ENSP00000431461

Symbol

• BGR
• CLECSF12
• DECTIN1
• BGR
• CD369
• CANDF4
• SCARE2
• DECTIN1
• CLECSF12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
PubMedID	0.74
biological term	0.72
transcription factor perturbation	0.68
cell type or tissue	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.38   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 669   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.38   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 669   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0