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Tbio
CLEC7A
C-type lectin domain family 7 member A

Protein Summary
Description
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298523
  • ENSP00000298523
  • ENSG00000172243
  • ENST00000304084
  • ENSP00000302569
  • ENST00000310002
  • ENSP00000312089
  • ENST00000349926
  • ENSP00000344723
  • ENST00000353231
  • ENSP00000266456
  • ENST00000396484
  • ENSP00000379743
  • ENST00000465100
  • ENSP00000436923
  • ENST00000529761
  • ENSP00000432876
  • ENST00000531192
  • ENSP00000434392
  • ENST00000533022
  • ENSP00000431461

Symbol
  • BGR
  • CLECSF12
  • DECTIN1
  • BGR
  • CD369
  • CANDF4
  • SCARE2
  • DECTIN1
  • CLECSF12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.74
biological term
0.72
transcription factor perturbation
0.68
cell type or tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.38   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 669   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.38   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 669   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.988
Data Source:  Reactome,STRINGDB
TLR2
Tchem
Novelty:  0.00023242
Score:  0.946
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.926
Data Source:  Reactome,STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.917
Data Source:  STRINGDB
CARD9
Tbio
Family:  Enzyme
Novelty:  0.00547101
Score:  0.845
Data Source:  STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
Score:  0.825
Data Source:  STRINGDB
TLR8
Tchem
Novelty:  0.0023384
Score:  0.773
Data Source:  STRINGDB
TLR4
Tchem
Novelty:  0.00010863
Score:  0.763
Data Source:  STRINGDB
TLR1
Tbio
Novelty:  0.00171909
Score:  0.753
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.736
Data Source:  STRINGDB
Pathways (7)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lectin-like oxidized LDL receptor 1 measurement
1
1
1
60.5
advanced glycosylation end product-specific receptor ligand measurement
1
1
1
18
self reported educational attainment
1
1
1
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lectin-like oxidized LDL receptor 1 measurement
1
60.5
advanced glycosylation end product-specific receptor ligand measurement
1
18
self reported educational attainment
1
1.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 7A
VGNC:8379
473361
Macaque
C-type lectin domain containing 7A
574356
Mouse
MGI:1861431
56644
Rat
RGD:1565140
502902
Dog
C-type lectin domain containing 7A
VGNC:39335
611385
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 7A
Macaque
C-type lectin domain containing 7A
Mouse
Rat
Dog
C-type lectin domain containing 7A
Publication Statistics
PubMed Score 864.38
PubMed score by year
PubTator Score 274.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title