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Tbio
PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

Protein Summary
Description
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). This gene encodes a serine/thr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321556
  • ENSP00000364204
  • ENSG00000158828

Symbol
  • BRPK
  • PARK6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
cellular component
0.88
kinase perturbation
0.81
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1261.74   (req: < 5)
Gene RIFs: 289   (req: <= 3)
Antibodies: 715   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1261.74   (req: >= 5)
Gene RIFs: 289   (req: > 3)
Antibodies: 715   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 82
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (234)
HSP90AA4P
Tdark
p_int:  0.999999938
p_ni:  6.1e-8
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.99999875
p_ni:  0.00000125
Data Source:  BioPlex
HSP90AA5P
Tdark
p_int:  0.999992869
p_ni:  0.000007131
Data Source:  BioPlex
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.999260833
p_ni:  0.000739167
Score:  0.635
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
p_int:  0.997043726
p_ni:  0.002956274
Score:  0.855
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.994156372
p_ni:  0.005843628
Data Source:  BioPlex
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.982209538
p_ni:  0.017790462
Score:  0.438
Data Source:  BioPlex,STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
p_int:  0.871341159
p_ni:  0.128658841
Data Source:  BioPlex
PSMD11
Tbio
Family:  Enzyme
Novelty:  0.02148951
p_int:  0.870068608
p_ni:  0.129931392
Data Source:  BioPlex
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.825217217
p_ni:  0.174782783
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell death genes
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
FOXO-mediated transcription
FOXO-mediated transcription of cell death genes
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (99)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
84.6
mean corpuscular volume
1
1
1
83.5
alkaline phosphatase measurement
2
2
1
8.4
76.1
apolipoprotein A 1 measurement
1
1
1
71.5
lymphocyte count
2
2
2
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
84.6
mean corpuscular volume
1
83.5
alkaline phosphatase measurement
1
8.4
76.1
apolipoprotein A 1 measurement
1
71.5
lymphocyte count
2
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PTEN induced putative kinase 1
VGNC:1456
749028
Mouse
MGI:1916193
68943
Dog
PTEN induced putative kinase 1
VGNC:44567
100688445
Horse
PTEN induced putative kinase 1
VGNC:21458
100071784
Cow
PTEN induced putative kinase 1
VGNC:32904
510683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PTEN induced putative kinase 1
Mouse
Dog
PTEN induced putative kinase 1
Horse
PTEN induced putative kinase 1
Cow
PTEN induced putative kinase 1
Publication Statistics
PubMed Score 1261.74
PubMed score by year
PubTator Score 694.86
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title