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Tbio
CARD11
Caspase recruitment domain-containing protein 11

Protein Summary
Description
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Whe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396946
  • ENSP00000380150
  • ENSG00000198286

Symbol
  • CARMA1
  • PPBL
  • BENTA
  • BIMP3
  • IMD11
  • CARMA1
  • IMD11A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
cell type or tissue
0.78
kinase
0.72
tissue sample
0.63
biological term
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.78   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.78   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
BCL10
Tbio
Novelty:  0.00253704
Score:  0.999
Data Source:  Reactome,STRINGDB
MALT1
Tchem
Novelty:  0.00367231
Score:  0.995
Data Source:  Reactome,STRINGDB
PRKCQ
Tchem
Family:  Kinase
Novelty:  0.00562719
Score:  0.994
Data Source:  Reactome,STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.993
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.968
Data Source:  Reactome,STRINGDB
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.967
Data Source:  STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.965
Data Source:  Reactome,STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
Score:  0.964
Data Source:  Reactome,STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
Score:  0.961
Data Source:  Reactome,STRINGDB
REL
Tbio
Family:  TF
Novelty:  0.00038265
Score:  0.958
Data Source:  STRINGDB
Pathways (26)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Downstream TCR signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
8
9
97.2
eosinophil count
3
4
5
90.2
BMI-adjusted waist circumference
2
5
5
81.1
platelet count
2
2
2
75.4
2
2
0
1.1
70.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
9
97.2
eosinophil count
5
90.2
BMI-adjusted waist circumference
5
81.1
platelet count
2
75.4
0
1.1
70.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase recruitment domain family member 11
VGNC:4292
463235
Mouse
MGI:1916978
108723
Dog
caspase recruitment domain family member 11
VGNC:38714
489887
Horse
caspase recruitment domain family member 11
VGNC:16053
100058981
Cow
caspase recruitment domain family member 11
VGNC:26761
515377
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase recruitment domain family member 11
Mouse
Dog
caspase recruitment domain family member 11
Horse
caspase recruitment domain family member 11
Cow
caspase recruitment domain family member 11
Publication Statistics
PubMed Score 169.78
PubMed score by year
PubTator Score 118.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title