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Tbio
CARD11
Caspase recruitment domain-containing protein 11

Protein Summary
Description
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Whe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396946
  • ENSP00000380150
  • ENSG00000198286

Symbol
  • CARMA1
  • PPBL
  • BENTA
  • BIMP3
  • IMD11
  • CARMA1
  • IMD11A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
cell type or tissue
0.78
kinase
0.72
tissue sample
0.63
biological term
0.58


Related Tools
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.5   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.5   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
6.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase recruitment domain family member 11
VGNC:4292
463235
Mouse
MGI:1916978
108723
Dog
caspase recruitment domain family member 11
VGNC:38714
489887
Horse
caspase recruitment domain family member 11
VGNC:16053
100058981
Cow
caspase recruitment domain family member 11
VGNC:26761
515377
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase recruitment domain family member 11
Mouse
Dog
caspase recruitment domain family member 11
Horse
caspase recruitment domain family member 11
Cow
caspase recruitment domain family member 11
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BXL7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Downstream TCR signaling
Gene Ontology Terms (30)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (126)
1 – 10 of 126
BCL10
Tbio
Novelty: 0.00253704
Score: 0.999
Data Source: Reactome,STRINGDB
MALT1
Tchem
Novelty: 0.00367231
Score: 0.995
Data Source: Reactome,STRINGDB
PRKCQ
Tchem
Family: Kinase
Novelty: 0.00562719
Score: 0.994
Data Source: Reactome,STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.993
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.968
Data Source: Reactome,STRINGDB
PRKCB
Tchem
Family: Kinase
Novelty: 0.00189802
Score: 0.967
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.965
Data Source: Reactome,STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00090202
Score: 0.964
Data Source: Reactome,STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.961
Data Source: Reactome,STRINGDB
REL
Tbio
Family: TF
Novelty: 0.00038265
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  157.50

PubMed score by year
PubTator Score  118.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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