Tbio CARD11 Caspase recruitment domain-containing protein 11

Protein Summary

Description

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BXL7
• A4D1Z7
• Q2NKN7
• Q548H3

Gene Name

• CARD11

Ensembl ID

• ENST00000396946
• ENSP00000380150
• ENSG00000198286

Symbol

• CARMA1
• PPBL
• BENTA
• BIMP3
• IMD11
• CARMA1
• IMD11A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.9
cell type or tissue	0.78
kinase	0.72
tissue sample	0.63
biological term	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.49   (req: < 5)

Gene RIFs: 90   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.49   (req: >= 5)

Gene RIFs: 90   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0