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Tbio
HEMGN
Hemogen

Protein Summary
Description
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259456
  • ENSP00000259456
  • ENSG00000136929
  • ENST00000616898
  • ENSP00000480020

Symbol
  • EDAG
  • NDR
  • NDR
  • EDAG
  • CT155
  • EDAG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
virus perturbation
0.97
cell type or tissue
0.7
tissue
0.47
cell line
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.7   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.7   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0