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Tbio
BCL2L13
Bcl-2-like protein 13

Protein Summary
Description
May promote the activation of caspase-3 and apoptosis. This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317582
  • ENSP00000318883
  • ENSG00000099968
  • ENST00000399782
  • ENSP00000382682
  • ENST00000418951
  • ENSP00000410019
  • ENST00000493680
  • ENSP00000434764
  • ENST00000543133
  • ENSP00000437667

Symbol
  • MIL1
  • MIL1
  • BCL-RAMBO
  • Bcl2-L-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.94
virus perturbation
0.9
transcription factor binding site profile
0.85
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.81   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.81   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
88.3
eosinophil count
2
1
2
65.9
leukocyte count
1
1
1
43
lymphocyte percentage of leukocytes
1
1
1
36.9
neutrophil percentage of leukocytes
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
88.3
eosinophil count
2
65.9
leukocyte count
1
43
lymphocyte percentage of leukocytes
1
36.9
neutrophil percentage of leukocytes
1
25.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (36)
1 – 10 of 36
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.999999999
Data Source: BioPlex
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
p_int: 0.999987778
p_ni: 0.000012222
Score: 0.409
Data Source: BioPlex,STRINGDB
SLC7A1
Tbio
Family: Transporter
Novelty: 0.00197313
p_int: 0.998521393
p_ni: 0.000001442
p_wrong: 0.001477165
Data Source: BioPlex
GABARAPL2
Tbio
Novelty: 0.0022546
Score: 0.884
Data Source: STRINGDB
GABARAPL1
Tbio
Novelty: 0.00212657
Score: 0.855
Data Source: STRINGDB
GABARAP
Tbio
Novelty: 0.00444901
Score: 0.841
Data Source: STRINGDB
CNEP1R1
Tbio
Family: Enzyme
Novelty: 0.68482554
Score: 0.678
Data Source: STRINGDB
CHKA
Tchem
Family: Kinase
Novelty: 0.00237839
Score: 0.632
Data Source: STRINGDB
FAM57A
Tdark
Novelty: 0.16634409
Score: 0.612
Data Source: STRINGDB
BCL2L14
Tbio
Novelty: 0.03980069
Score: 0.61
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.81

PubMed score by year
PubTator Score  21.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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