Tbio NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit

Protein Summary

Description

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9BXJ9
• D3DNY6
• Q52LG9
• Q8IWH4
• Q8NEV2
• Q9H8P6

Gene Name

• NAA15

Ensembl ID

• ENST00000296543
• ENSP00000296543
• ENSG00000164134

Symbol

• GA19
• NARG1
• NATH
• TBDN100
• Ga19
• NATH
• TBDN
• MRD50
• NARG1
• NAT1P
• TBDN100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
transcription factor binding site profile	0.78
microRNA	0.77
tissue	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / N-alpha-acetyltransferase 15, Nata Auxiliary Subunit

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / N-alpha-acetyltransferase 15, Nata Auxiliary Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.21   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.21   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

NAA16

Tbio

Family:  Enzyme

Novelty:  0.23261397

p_int:  0.999999998

p_wrong:  2e-9

Score:  0.982

Data Source:  BioPlex,STRINGDB

HYPK

Tbio

Novelty:  0.085555

p_int:  0.999999962

p_ni:  3.8e-8

Score:  0.982

Data Source:  BioPlex,STRINGDB

NAA50

Tchem

Family:  Enzyme

Novelty:  0.01843508

p_int:  0.999999883

p_ni:  1.17e-7

Score:  0.995

Data Source:  BioPlex,STRINGDB

NAA10

Tbio

Family:  Enzyme

Novelty:  0.00086809

p_int:  0.999984236

p_ni:  0.000015765

Score:  0.999

Data Source:  BioPlex,STRINGDB

ARRB2

Tbio

Novelty:  0.00148149

p_int:  0.999933599

p_ni:  0.000066401

Data Source:  BioPlex

BTF3

Tbio

Novelty:  0.01198537

p_int:  0.999238814

p_ni:  0.000761183

p_wrong:  3e-9

Score:  0.272

Data Source:  BioPlex,STRINGDB

UBD

Tbio

Novelty:  0.00657227

p_int:  0.999172454

p_ni:  0.000827545

p_wrong:  1e-9

Data Source:  BioPlex

TRAFD1

Tbio

Novelty:  0.144593

p_int:  0.9990725

p_ni:  0.0009275

Score:  0.189

Data Source:  BioPlex,STRINGDB

FGB

Tbio

Novelty:  0.00437751

p_int:  0.99894731

p_ni:  0.001052687

p_wrong:  3e-9

Data Source:  BioPlex

SNRNP27

Tbio

Novelty:  0.0175187

p_int:  0.998680986

p_ni:  0.001319014

Score:  0.162

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (33)

WikiPathways (33)

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1 – 5 of 33

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Endoderm Differentiation	552 targets	WP2853_r105583
WikiPathways	Endoderm Differentiation	552 targets	WP2853_r105583
WikiPathways	Endoderm Differentiation	552 targets	WP2853_r105583
WikiPathways	Endoderm Differentiation	552 targets	WP2853_r105583
WikiPathways	Endoderm Differentiation	552 targets	WP2853_r105583

Name	Explore in Pharos	Explore in Source
Endoderm Differentiation	552 targets	WP2853_r105583
Endoderm Differentiation	552 targets	WP2853_r105583
Endoderm Differentiation	552 targets	WP2853_r105583
Endoderm Differentiation	552 targets	WP2853_r105583
Endoderm Differentiation	552 targets	WP2853_r105583

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (2)

Components (6)

Processes (7)

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GO Term	Evidence	Assigned by
ribosome binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

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1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	1	1	0	1.6	11.1

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	0	1.6	11.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Angiogenesis
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Disease mutation
Mental retardation

GWAS Trait Find Similar Targets

No Header	No Header
central corneal thickness

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	N(alpha)-acetyltransferase 15, NatA auxiliary subunit		461495
Macaque	N(alpha)-acetyltransferase 15, NatA auxiliary subunit		697123
Mouse	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	MGI:1922088	74838
Rat	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	RGD:1310984	310399
Dog	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	VGNC:54810	483817

Species	Name	OMA	EggNOG	Inparanoid
Chimp	N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Macaque	N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Mouse	N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Rat	N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Dog	N(alpha)-acetyltransferase 15, NatA auxiliary subunit

Publication Statistics

PubMed Score 191.21

PubMed score by year

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PubTator Score 127.96

PubTator score by year

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Related Publications

Text Mined References (34)

GeneRif Annotations (13)

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10

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PMID	Year	Title