Tbio NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit

Protein Summary

Description

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9BXJ9
• D3DNY6
• Q52LG9
• Q8IWH4
• Q8NEV2
• Q9H8P6

Gene Name

• NAA15

Ensembl ID

• ENST00000296543
• ENSP00000296543
• ENSG00000164134

Symbol

• GA19
• NARG1
• NATH
• TBDN100
• Ga19
• NATH
• TBDN
• MRD50
• NARG1
• NAT1P
• TBDN100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
transcription factor binding site profile	0.78
microRNA	0.77
tissue	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / N-alpha-acetyltransferase 15, Nata Auxiliary Subunit

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / N-alpha-acetyltransferase 15, Nata Auxiliary Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.01   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.01   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0