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Tbio
AMN
Protein amnionless

Protein Summary
Description
Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity). The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299155
  • ENSP00000299155
  • ENSG00000166126

Symbol
  • PRO1028
  • amnionless
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.85
cellular component
0.74
gene perturbation
0.67
tissue sample
0.65
PubMedID
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.24   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.24   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (23)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defective AMN causes hereditary megaloblastic anemia 1
Reactome
Defective CUBN causes hereditary megaloblastic anemia 1
Reactome
Defects in cobalamin (B12) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective AMN causes hereditary megaloblastic anemia 1
Defective CUBN causes hereditary megaloblastic anemia 1
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (39)
1 – 10 of 39
CUBN
Tbio
Novelty: 0.00667892
Score: 0.993
Data Source: Reactome,STRINGDB
GIF
Tbio
Novelty: 0.00060948
Score: 0.978
Data Source: Reactome,STRINGDB
APOA1
Tbio
Novelty: 0.0001431
Score: 0.941
Data Source: Reactome,STRINGDB
LRP2
Tbio
Novelty: 0.002005
Score: 0.784
Data Source: STRINGDB
ABCG4
Tbio
Family: Transporter
Novelty: 0.00837484
Score: 0.673
Data Source: STRINGDB
TCN2
Tbio
Novelty: 0.0018819
Score: 0.65
Data Source: STRINGDB
DAB2
Tbio
Novelty: 0.00455296
Score: 0.646
Data Source: STRINGDB
TCN1
Tbio
Novelty: 0.00420205
Score: 0.641
Data Source: STRINGDB
CDC42BPB
Tbio
Family: Kinase
Novelty: 0.23112171
Score: 0.621
Data Source: STRINGDB
AMN1
Tbio
Novelty: 0.06148141
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.24

PubMed score by year
PubTator Score  7.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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