Protein Summary
Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity). The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.24 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 49 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.24 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 49 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (23)
Reactome (14)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Reactome | Defects in vitamin and cofactor metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Defects in cobalamin (B12) metabolism | ||||
Defects in vitamin and cofactor metabolism | ||||
Gene Ontology Terms (18)
Functions (1)
Components (10)
Processes (7)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Protein-Protein Interactions (39)
1 – 10 of 39
CUBN
Novelty: 0.00667892
Score: 0.993
Data Source: Reactome,STRINGDB
GIF
Novelty: 0.00060948
Score: 0.978
Data Source: Reactome,STRINGDB
APOA1
Novelty: 0.0001431
Score: 0.941
Data Source: Reactome,STRINGDB
LRP2
Novelty: 0.002005
Score: 0.784
Data Source: STRINGDB
ABCG4
Family: Transporter
Novelty: 0.00837484
Score: 0.673
Data Source: STRINGDB
TCN2
Novelty: 0.0018819
Score: 0.65
Data Source: STRINGDB
DAB2
Novelty: 0.00455296
Score: 0.646
Data Source: STRINGDB
TCN1
Novelty: 0.00420205
Score: 0.641
Data Source: STRINGDB
CDC42BPB
Family: Kinase
Novelty: 0.23112171
Score: 0.621
Data Source: STRINGDB
AMN1
Novelty: 0.06148141
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score 19.24
PubMed score by year
PubTator Score 7.12
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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