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Tbio
TBC1D10A
TBC1 domain family member 10A

Protein Summary
Description
Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215790
  • ENSP00000215790
  • ENSG00000099992
  • ENST00000403477
  • ENSP00000384996

Symbol
  • EPI64
  • TBC1D10
  • EPI64
  • TBC1D10
  • dJ130H16.1
  • dJ130H16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
transcription factor
0.62
transcription factor binding site profile
0.57
tissue sample
0.55
cell line
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.51   (req: < 5)
View Publications
Gene RIFs: 9   (req: <= 3)
View Gene RIFs
Antibodies: 122   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.51   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
EFO_0007985
1
1
1
40.4
platelet count
EFO_0004309
1
1
1
28.7
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
EFO_0007985
1
40.4
platelet count
EFO_0004309
1
28.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
TBC1 domain family, member 10a
MGI:2144164
103724
Rat
TBC1 domain family, member 10a
RGD:1311641
360968
Horse
TBC1 domain family member 10A
VGNC:50979
100064004
Cow
TBC1 domain family member 10A
VGNC:53923
511933
Pig
TBC1 domain family member 10A
100156070
Species
Name
OMA
EggNOG
Inparanoid
Mouse
TBC1 domain family, member 10a
Rat
TBC1 domain family, member 10a
Horse
TBC1 domain family member 10A
Cow
TBC1 domain family member 10A
Pig
TBC1 domain family member 10A
Pathways (5)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
612 targets
R-HSA-199991
Reactome
Rab regulation of trafficking
123 targets
R-HSA-9007101
Reactome
TBC/RABGAPs
45 targets
R-HSA-8854214
Reactome
Vesicle-mediated transport
725 targets
R-HSA-5653656
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
612 targets
R-HSA-199991
Rab regulation of trafficking
123 targets
R-HSA-9007101
TBC/RABGAPs
45 targets
R-HSA-8854214
Vesicle-mediated transport
725 targets
R-HSA-5653656
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
PDZ domain binding
Inferred from Physical Interaction (IPI)
UniProtKB
cadherin binding
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
GTPase activator activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Rab GTPase binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
guanyl-nucleotide exchange factor activity
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
FGL1
Tbio
Novelty: 0.02650803
p_int: 1
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.66
Data Source: BioPlex,STRINGDB
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.999973101
p_ni: 0.000023455
p_wrong: 0.000003443
Score: 0.557
Data Source: BioPlex,STRINGDB
CNOT11
Tbio
Novelty: 0.01687183
p_int: 0.990219413
p_ni: 0.000003132
p_wrong: 0.009777455
Score: 0.243
Data Source: BioPlex,STRINGDB
RAB35
Tbio
Family: Enzyme
Novelty: 0.01514601
Score: 0.986
Data Source: STRINGDB
SYTL1
Tbio
Novelty: 0.09070371
Score: 0.955
Data Source: Reactome,STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.949
Data Source: Reactome,STRINGDB
RAB22A
Tbio
Family: Enzyme
Novelty: 0.02344687
Score: 0.746
Data Source: STRINGDB
RAB27A
Tchem
Family: Enzyme
Novelty: 0.00369416
Score: 0.714
Data Source: STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.00357766
Score: 0.702
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.51

PubMed score by year
PubTator Score  5.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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