You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC25A2
Mitochondrial ornithine transporter 2

Protein Summary
Description
Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. This intronless gene encodes a protein that localizes to the mitochondrial inner membrane and likely functions as a transporter of small molecules such as ornithine. This gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239451
  • ENSP00000239451
  • ENSG00000120329

Symbol
  • ORNT2
  • ORC2
  • ORNT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
cellular component
0.64
tissue sample
0.53
metabolite
0.45
cell line
0.41


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
21.5
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 2
701587
Xenopus
solute carrier family 25 member 15
XB-GENE-973185
100038284
Zebrafish
ZDB-GENE-060526-35
565335
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 2
Xenopus
solute carrier family 25 member 15
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BXI2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Urea cycle
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Urea cycle
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (13)
1 – 10 of 13
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.878506573
p_ni:  0.121493427
Data Source:  BioPlex
HERC3
Tbio
Family:  Enzyme
Novelty:  0.05231675
p_int:  0.782742099
p_ni:  0.217257901
Score:  0.319
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
Score:  0.555
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.555
Data Source:  STRINGDB
OAT
Tchem
Family:  Enzyme
Novelty:  0.00125611
Score:  0.548
Data Source:  STRINGDB
PCDHB3
Tdark
Novelty:  0.51391546
Score:  0.494
Data Source:  STRINGDB
PCDHGA3
Tbio
Novelty:  0.2993491
Score:  0.463
Data Source:  STRINGDB
WDR55
Tdark
Novelty:  0.51900003
Score:  0.457
Data Source:  STRINGDB
PCDHAC1
Tdark
Novelty:  0.3734734
Score:  0.454
Data Source:  STRINGDB
ZMAT2
Tbio
Novelty:  0.16771752
Score:  0.439
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.19

PubMed score by year
PubTator Score  4.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer