Tbio Q9BXH1 Bcl-2-binding component 3

Protein Summary

Description

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338). This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9BXH1
• B9EGI3
• O00171
• Q96PG9

Gene Name

• BBC3

Ensembl ID

• ENST00000341983
• ENSP00000341155
• ENSG00000105327
• ENST00000439096
• ENSP00000395862

Symbol

• PUMA
• JFY1
• PUMA
• JFY-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.86
virus perturbation	0.83
transcription factor binding site profile	0.82
transcription factor	0.78
cell type or tissue	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.76   (req: < 5)

Gene RIFs: 192   (req: <= 3)

Antibodies: 746   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.76   (req: >= 5)

Gene RIFs: 192   (req: > 3)

Antibodies: 746   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0