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Tbio
BBC3
Bcl-2-binding component 3

Protein Summary
Description
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338). This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341983
  • ENSP00000341155
  • ENSG00000105327
  • ENST00000439096
  • ENSP00000395862

Symbol
  • PUMA
  • JFY1
  • PUMA
  • JFY-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.86
virus perturbation
0.83
transcription factor binding site profile
0.82
transcription factor
0.78
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.94   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 746   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.94   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 746   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
2
82.5
appendicular lean mass
1
1
2
82.5
myeloid white cell count
1
1
2
76.7
myeloid white cell count
1
1
2
76.7
monocyte count
1
1
2
15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
82.5
appendicular lean mass
2
82.5
myeloid white cell count
2
76.7
myeloid white cell count
2
76.7
monocyte count
2
15
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
FOXO-mediated transcription
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of PUMA and translocation to mitochondria
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
FOXO-mediated transcription
Gene Ontology Terms (27)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
GOC
Protein-Protein Interactions (55)
1 – 10 of 55
BCL2L2
Tchem
Novelty: 0.00430896
p_int: 0.999999959
p_ni: 4e-8
Score: 0.833
Data Source: BioPlex,STRINGDB
MCL1
Tchem
Novelty: 0.00046181
p_int: 0.999999848
p_ni: 9e-8
p_wrong: 6.2e-8
Score: 0.984
Data Source: BioPlex,STRINGDB
BCL2L1
Tchem
Novelty: 0.00018414
Score: 0.986
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.978
Data Source: STRINGDB
BCL2A1
Tchem
Novelty: 0.00088899
Score: 0.976
Data Source: STRINGDB
PMAIP1
Tbio
Novelty: 0.00198406
Score: 0.972
Data Source: STRINGDB
BCL2
Tclin
Novelty: 0.00608635
Score: 0.972
Data Source: Reactome,STRINGDB
BID
Tbio
Novelty: 0.01264688
Score: 0.956
Data Source: STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
Score: 0.937
Data Source: STRINGDB
TP73
Tbio
Family: TF
Novelty: 0.00667737
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  102.94

PubMed score by year
PubTator Score  19.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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