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Tchem
GPR174
Probable G-protein coupled receptor 174

Protein Summary
Description
Putative receptor for purines coupled to G-proteins. This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276077
  • ENSP00000276077
  • ENSG00000147138
  • ENST00000645147
  • ENSP00000494310

Symbol
  • FKSG79
  • GPCR17
  • LYPSR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.59
cell line
0.54
tissue sample
0.54
tissue
0.5
transcription factor
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (11)
lysophosphatidylserine
Rendered image for lysophosphatidylserine
CHEMBL3577171
Rendered image for CHEMBL3577171
CHEMBL3577174
Rendered image for CHEMBL3577174
CHEMBL3577172
Rendered image for CHEMBL3577172
CHEMBL3577175
Rendered image for CHEMBL3577175
CHEMBL3577176
Rendered image for CHEMBL3577176
CHEMBL3577173
Rendered image for CHEMBL3577173
CHEMBL3577168
Rendered image for CHEMBL3577168
CHEMBL3577265
Rendered image for CHEMBL3577265
CHEMBL3577263
Rendered image for CHEMBL3577263
Protein-Protein Interactions (74)
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
Score:  0.738
Data Source:  STRINGDB
P2RY10
Tchem
Family:  GPCR
Novelty:  0.12674578
Score:  0.705
Data Source:  STRINGDB
ADGRD2
Tdark
Family:  GPCR
Novelty:  1.00566581
Score:  0.687
Data Source:  STRINGDB
ITK
Tclin
Family:  Kinase
Novelty:  0.00054195
Score:  0.687
Data Source:  STRINGDB
IKZF3
Tbio
Family:  TF
Novelty:  0.01038728
Score:  0.668
Data Source:  STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
Score:  0.658
Data Source:  STRINGDB
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
Score:  0.645
Data Source:  STRINGDB
PTPN22
Tchem
Family:  Enzyme
Novelty:  0.00168847
Score:  0.642
Data Source:  STRINGDB
ZAP70
Tchem
Family:  Kinase
Novelty:  0.0011564
Score:  0.63
Data Source:  STRINGDB
GRAP2
Tbio
Novelty:  0.00503901
Score:  0.621
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
30.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
30.1
Find similar targets by:
IDG Resources
Genetic Construct
GPR174-Tango
image for GPR174-Tango
Details:
  • Vector:  addgene66339
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR174-Tango
Order Genetic Construct from:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 174
VGNC:12374
100613557
Mouse
MGI:2685222
213439
Rat
RGD:1564689
302373
Dog
G protein-coupled receptor 174
VGNC:41417
100683878
Horse
G protein-coupled receptor 174
VGNC:18528
100071745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 174
Mouse
Rat
Dog
G protein-coupled receptor 174
Horse
G protein-coupled receptor 174
Publication Statistics
PubMed Score 14.40
PubMed score by year
PubTator Score 9.00
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title