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Tchem
HCAR1
Hydroxycarboxylic acid receptor 1

Protein Summary
Description
Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway. G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432564
  • ENSP00000389255
  • ENSG00000196917

Symbol
  • GPR104
  • GPR81
  • HCA1
  • HCA1
  • GPR81
  • LACR1
  • FKSG80
  • GPR104
  • TAGPCR
  • TA-GPCR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.61
gene perturbation
0.53
cell line
0.51
cell type or tissue
0.43
tissue
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.4   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.4   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 156
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Mouse
image for
Details:
  • Allele:  Insertion
Active Ligands (156)
1 – 10 of 156
3,5-dihydroxybenzoic acid
Rendered image for 3,5-dihydroxybenzoic acid
CHEMBL4642043
Rendered image for CHEMBL4642043
CHEMBL4641579
Rendered image for CHEMBL4641579
compound 2 [PMID: 24486398]
Rendered image for compound 2 [PMID: 24486398]
&gamma;-hydroxybutyric acid
Rendered image for &gamma;-hydroxybutyric acid
D-lactic acid
Rendered image for D-lactic acid
CHEMBL4632482
Rendered image for CHEMBL4632482
CHEMBL3717084
Rendered image for CHEMBL3717084
CHEMBL3717773
Rendered image for CHEMBL3717773
CHEMBL3718324
Rendered image for CHEMBL3718324
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
7
7
98.2
waist-hip ratio
1
18
18
97.5
BMI-adjusted waist-hip ratio
2
18
18
97.5
waist circumference
1
11
11
94.2
BMI-adjusted waist circumference
1
10
10
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
98.2
waist-hip ratio
18
97.5
BMI-adjusted waist-hip ratio
18
97.5
waist circumference
11
94.2
BMI-adjusted waist circumference
10
91.9
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxycarboxylic acid receptor 1
VGNC:13104
452331
Mouse
MGI:2441671
243270
Rat
RGD:1586364
689936
Horse
hydroxycarboxylic acid receptor 1
VGNC:18705
100060403
Opossum
hydroxycarboxylic acid receptor 1
100022345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxycarboxylic acid receptor 1
Mouse
Rat
Horse
hydroxycarboxylic acid receptor 1
Opossum
hydroxycarboxylic acid receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BXC0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hydroxycarboxylic acid-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Hydroxycarboxylic acid-binding receptors
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (237)
1 – 10 of 237
CERS5
Tbio
Family:  TF
Novelty:  0.02984012
p_int:  0.997919549
p_ni:  0.001626195
p_wrong:  0.000454256
Data Source:  BioPlex
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.991724761
p_ni:  0.008275239
Data Source:  BioPlex
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.817923448
p_ni:  0.182075591
p_wrong:  9.61e-7
Data Source:  BioPlex
SUCNR1
Tchem
Family:  GPCR
Novelty:  0.01482891
Score:  0.92
Data Source:  STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.919
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.919
Data Source:  STRINGDB
OXGR1
Tchem
Family:  GPCR
Novelty:  0.03623646
Score:  0.916
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.915
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.915
Data Source:  STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  74.40

PubMed score by year
PubTator Score  22.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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