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Tchem
HCAR1
Hydroxycarboxylic acid receptor 1

Protein Summary
Description
Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway. G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432564
  • ENSP00000389255
  • ENSG00000196917

Symbol
  • GPR104
  • GPR81
  • HCA1
  • HCA1
  • GPR81
  • LACR1
  • FKSG80
  • GPR104
  • TAGPCR
  • TA-GPCR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.61
gene perturbation
0.53
cell line
0.51
cell type or tissue
0.43
tissue
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.59   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.59   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 156
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0