Tchem HCAR1 Hydroxycarboxylic acid receptor 1

Protein Summary

Description

Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway. G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]

Uniprot Accession IDs

• Q9BXC0
• B2R9X4
• Q3Y5J3
• Q4VBN1
• Q6NXU5

Gene Name

• HCAR1

Ensembl ID

• ENST00000432564
• ENSP00000389255
• ENSG00000196917

Symbol

• GPR104
• GPR81
• HCA1
• HCA1
• GPR81
• LACR1
• FKSG80
• GPR104
• TAGPCR
• TA-GPCR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.61
gene perturbation	0.53
cell line	0.51
cell type or tissue	0.43
tissue	0.43

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Hydroxycarboxylic Acid Receptor / Hydroxycarboxylic Acid Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.59   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 351   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.59   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 156

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0