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Tchem
TSSK1B
Testis-specific serine/threonine-protein kinase 1

Protein Summary
Description
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390666
  • ENSP00000375081
  • ENSG00000212122

Symbol
  • SPOGA1
  • SPOGA4
  • STK22A
  • STK22D
  • TSSK1
  • TSK1
  • TSSK1
  • FKSG81
  • SPOGA4
  • STK22D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.73
gene perturbation
0.71
cell type or tissue
0.57
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ceritinib
chemical structure image
Protein-Protein Interactions (44)
1 – 10 of 44
CRYBG3
Tdark
Family: Enzyme
Novelty: 0.24063491
p_int: 0.999998172
p_ni: 0.000001828
Score: 0.234
Data Source: BioPlex,STRINGDB
CEP131
Tbio
Novelty: 0.02562073
p_int: 0.999983718
p_ni: 0.000016281
p_wrong: 1e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
GPHN
Tbio
Novelty: 0.0020752
p_int: 0.999925548
p_ni: 0.000074452
Score: 0.295
Data Source: BioPlex,STRINGDB
SNX24
Tdark
Novelty: 0.20838126
p_int: 0.99744517
p_ni: 0.001190281
p_wrong: 0.00136455
Score: 0.677
Data Source: BioPlex,STRINGDB
GAPVD1
Tbio
Family: Enzyme
Novelty: 0.13142098
p_int: 0.968268304
p_ni: 0.031731694
p_wrong: 1e-9
Score: 0.729
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.930866466
p_ni: 0.069133534
Score: 0.157
Data Source: BioPlex,STRINGDB
MKI67
Tbio
Novelty: 0.00580699
p_int: 0.807316875
p_ni: 0.192683125
Score: 0.261
Data Source: BioPlex,STRINGDB
HSPA2
Tbio
Novelty: 0.01696667
p_int: 0.761897535
p_ni: 0.238102465
Score: 0.677
Data Source: BioPlex,STRINGDB
TSKS
Tbio
Family: Enzyme
Novelty: 0.0886446
Score: 0.829
Data Source: STRINGDB
MFAP1
Tbio
Novelty: 0.15311456
Score: 0.64
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.97

PubMed score by year
PubTator Score  5.76

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer