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Tbio
TSSK6
Testis-specific serine/threonine-protein kinase 6

Protein Summary
Description
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585580
  • ENSP00000466477
  • ENSG00000178093
  • ENST00000587522
  • ENSP00000466056

Symbol
  • SSTK
  • CT72
  • SSTK
  • TSSK4
  • FKSG82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
transcription factor binding site profile
0.89
gene perturbation
0.76
histone modification site profile
0.74
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (53)
1 – 10 of 53
TSKS
Tbio
Family: Enzyme
Novelty: 0.0886446
Score: 0.792
Data Source: STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
Score: 0.758
Data Source: STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.725
Data Source: STRINGDB
ODF1
Tbio
Novelty: 0.01272872
Score: 0.663
Data Source: STRINGDB
HSD17B7
Tchem
Family: Enzyme
Novelty: 0.04295724
Score: 0.662
Data Source: STRINGDB
TNP1
Tbio
Novelty: 0.01264731
Score: 0.637
Data Source: STRINGDB
IZUMO4
Tdark
Novelty: 0.76836026
Score: 0.635
Data Source: STRINGDB
IZUMO1
Tbio
Novelty: 0.01839953
Score: 0.617
Data Source: STRINGDB
FAM117A
Tdark
Novelty: 1.51056338
Score: 0.609
Data Source: STRINGDB
HSPA1A
Tchem
Novelty: 0.00069195
Score: 0.599
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.68

PubMed score by year
PubTator Score  3.45

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer