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Tbio
TSSK6
Testis-specific serine/threonine-protein kinase 6

Protein Summary
Description
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585580
  • ENSP00000466477
  • ENSG00000178093
  • ENST00000587522
  • ENSP00000466056

Symbol
  • SSTK
  • CT72
  • SSTK
  • TSSK4
  • FKSG82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
transcription factor binding site profile
0.89
gene perturbation
0.76
histone modification site profile
0.74
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.45   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.45   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
Score:  0.792
Data Source:  STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
Score:  0.758
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.725
Data Source:  STRINGDB
ODF1
Tbio
Novelty:  0.01272872
Score:  0.663
Data Source:  STRINGDB
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
Score:  0.662
Data Source:  STRINGDB
TNP1
Tbio
Novelty:  0.01264731
Score:  0.637
Data Source:  STRINGDB
IZUMO4
Tdark
Novelty:  0.76836026
Score:  0.635
Data Source:  STRINGDB
IZUMO1
Tbio
Novelty:  0.01839953
Score:  0.617
Data Source:  STRINGDB
FAM117A
Tdark
Novelty:  1.51056338
Score:  0.609
Data Source:  STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.599
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
3
3
6.9
95.7
red blood cell distribution width
3
3
3
93.3
total cholesterol measurement
2
2
2
90
low density lipoprotein cholesterol measurement
3
2
2
3.3
89.7
platelet count
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
6.9
95.7
red blood cell distribution width
3
93.3
total cholesterol measurement
2
90
low density lipoprotein cholesterol measurement
2
3.3
89.7
platelet count
2
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2148775
83984
Rat
RGD:1559764
290670
Dog
testis specific serine kinase 6
476660
Cow
testis specific serine kinase 6
VGNC:50152
539707
Platypus
testis specific serine kinase 6
100088038
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
testis specific serine kinase 6
Cow
testis specific serine kinase 6
Platypus
testis specific serine kinase 6
Publication Statistics
PubMed Score 61.45
PubMed score by year
PubTator Score 3.45
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title