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Tdark
PLA2G12B
Group XIIB secretory phospholipase A2-like protein

Protein Summary
Description
Not known; does not seem to have catalytic activity. The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373032
  • ENSP00000362123
  • ENSG00000138308

Symbol
  • PLA2G13
  • GXIIB
  • FKSG71
  • PLA2G13
  • GXIIIsPLA2
  • sPLA2-GXIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
metabolite
0.93
cell type or tissue
0.61
PubMedID
0.61
cell line
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.57   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.57   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
55.3
smoking behaviour measurement
1
1
1
9.7
high density lipoprotein cholesterol measurement
1
1
1
7.9
systolic blood pressure
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
55.3
smoking behaviour measurement
1
9.7
high density lipoprotein cholesterol measurement
1
7.9
systolic blood pressure
1
4.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group XIIB
VGNC:13055
466292
Macaque
phospholipase A2 group XIIB
708031
Mouse
MGI:1917086
69836
Rat
RGD:1588484
367415
Dog
phospholipase A2 group XIIB
VGNC:44620
489045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group XIIB
Macaque
phospholipase A2 group XIIB
Mouse
Rat
Dog
phospholipase A2 group XIIB
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BX93-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (32)
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ether lipid metabolism
KEGG
Glycerophospholipid metabolism
KEGG
Fat digestion and absorption
KEGG
Vascular smooth muscle contraction
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Ether lipid metabolism
Glycerophospholipid metabolism
Fat digestion and absorption
Vascular smooth muscle contraction
Metabolic pathways
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (119)
1 – 10 of 119
CCPG1
Tbio
Novelty: 0.07685013
p_int: 0.759834349
p_ni: 0.240165651
Score: 0.313
Data Source: BioPlex,STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.874
Data Source: STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
Score: 0.808
Data Source: STRINGDB
PNPLA7
Tdark
Family: Enzyme
Novelty: 0.11025485
Score: 0.789
Data Source: STRINGDB
PLD4
Tbio
Family: Enzyme
Novelty: 0.11244493
Score: 0.774
Data Source: STRINGDB
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.771
Data Source: STRINGDB
APOA4
Tbio
Novelty: 0.00305835
Score: 0.766
Data Source: STRINGDB
PLA2G16
Tbio
Novelty: 0.02310886
Score: 0.763
Data Source: STRINGDB
PLA2G15
Tbio
Family: Enzyme
Novelty: 0.01546393
Score: 0.749
Data Source: STRINGDB
PLA2G2C
Tchem
Family: Enzyme
Novelty: 0.34619233
Score: 0.747
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.57

PubMed score by year
PubTator Score  4.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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