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Tchem
TRPM6
Transient receptor potential cation channel subfamily M member 6

Protein Summary
Description
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360774
  • ENSP00000354006
  • ENSG00000119121
  • ENST00000361255
  • ENSP00000354962
  • ENST00000449912
  • ENSP00000396672

Symbol
  • CHAK2
  • HSH
  • HMGX
  • HOMG
  • CHAK2
  • HOMG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cell type or tissue
0.66
tissue
0.61
virus perturbation
0.59
cell line
0.58


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.3   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.3   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
magnesium measurement
1
1
1
77.9
viral load
1
1
1
58.8
HIV-1 infection
1
1
1
58.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
magnesium measurement
1
77.9
viral load
1
58.8
HIV-1 infection
1
58.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 6
VGNC:8947
472957
Macaque
transient receptor potential cation channel subfamily M member 6
706119
Mouse
MGI:2675603
225997
Rat
RGD:1309942
293874
Dog
transient receptor potential cation channel subfamily M member 6
VGNC:47877
484163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 6
Macaque
transient receptor potential cation channel subfamily M member 6
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 6
Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Protein-Protein Interactions (73)
1 – 10 of 73
TRPM7
Tchem
Family: IC
Novelty: 0.00265096
Score: 0.877
Data Source: STRINGDB
TRPV5
Tchem
Family: IC
Novelty: 0.0055156
Score: 0.787
Data Source: STRINGDB
SLC41A1
Tbio
Family: Transporter
Novelty: 0.01442757
Score: 0.759
Data Source: STRINGDB
TRPV6
Tchem
Family: IC
Novelty: 0.00383629
Score: 0.733
Data Source: STRINGDB
CLDN16
Tbio
Novelty: 0.0092505
Score: 0.732
Data Source: STRINGDB
SLC41A2
Tbio
Family: Transporter
Novelty: 0.1720312
Score: 0.71
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.707
Data Source: STRINGDB
CNNM2
Tbio
Novelty: 0.03252541
Score: 0.697
Data Source: STRINGDB
TRPA1
Tclin
Family: IC
Novelty: 0.00093648
Score: 0.68
Data Source: STRINGDB
MGAM
Tclin
Family: Enzyme
Novelty: 0.00045865
Score: 0.679
Data Source: STRINGDB
Publication Statistics
PubMed Score  171.30

PubMed score by year
PubTator Score  100.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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