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Tbio
STRA6
Receptor for retinol uptake STRA6

Protein Summary
Description
Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A defic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323940
  • ENSP00000326085
  • ENSG00000137868
  • ENST00000395105
  • ENSP00000378537
  • ENST00000423167
  • ENSP00000413012
  • ENST00000432245
  • ENSP00000407176
  • ENST00000449139
  • ENSP00000410221
  • ENST00000535552
  • ENSP00000440238
  • ENST00000563965
  • ENSP00000456609
  • ENST00000574278
  • ENSP00000458827
  • ENST00000616000
  • ENSP00000479112

Symbol
  • MCOPS9
  • MCOPCB8
  • PP14296
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
gene perturbation
0.74
transcription factor
0.68
small molecule perturbation
0.65
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.53   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.53   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
1
2
2
83.6
1
1
1
49.5
glomerular filtration rate
1
1
1
49.5
BMI-adjusted hip circumference
1
2
2
47.5
diastolic blood pressure
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cups of coffee per day measurement
2
83.6
1
49.5
glomerular filtration rate
1
49.5
BMI-adjusted hip circumference
2
47.5
diastolic blood pressure
1
44.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stimulated by retinoic acid 6
VGNC:1599
453738
Macaque
stimulated by retinoic acid 6
701591
Mouse
MGI:107742
20897
Rat
RGD:1307551
363071
Dog
stimulated by retinoic acid 6
VGNC:46937
611518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stimulated by retinoic acid 6
Macaque
stimulated by retinoic acid 6
Mouse
Rat
Dog
stimulated by retinoic acid 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BX79-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (59)
1 – 10 of 59
RBP4
Tchem
Novelty:  0.00168442
Score:  0.986
Data Source:  Reactome,STRINGDB
RBP1
Tbio
Novelty:  0.00199929
Score:  0.974
Data Source:  STRINGDB
TTR
Tclin
Novelty:  0.0001199
Score:  0.964
Data Source:  Reactome,STRINGDB
CRABP1
Tbio
Novelty:  0.00284292
Score:  0.843
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.805
Data Source:  STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.741
Data Source:  STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.738
Data Source:  STRINGDB
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
Score:  0.672
Data Source:  STRINGDB
SDR9C7
Tbio
Family:  Enzyme
Novelty:  0.01618496
Score:  0.662
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.653
Data Source:  STRINGDB
Publication Statistics
PubMed Score  94.53

PubMed score by year
PubTator Score  47.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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