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Tbio
STRA6
Receptor for retinol uptake STRA6

Protein Summary
Description
Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A defic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323940
  • ENSP00000326085
  • ENSG00000137868
  • ENST00000395105
  • ENSP00000378537
  • ENST00000423167
  • ENSP00000413012
  • ENST00000432245
  • ENSP00000407176
  • ENST00000449139
  • ENSP00000410221
  • ENST00000535552
  • ENSP00000440238
  • ENST00000563965
  • ENSP00000456609
  • ENST00000574278
  • ENSP00000458827
  • ENST00000616000
  • ENSP00000479112

Symbol
  • MCOPS9
  • MCOPCB8
  • PP14296
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
gene perturbation
0.74
transcription factor
0.68
small molecule perturbation
0.65
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.58   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.58   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0