Tbio HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial

Protein Summary

Description

Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity. Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9BX68
• Q5TCW3
• HINT-2

Gene Name

• HINT2

Ensembl ID

• ENST00000259667
• ENSP00000259667
• ENSG00000137133

Symbol

• HIT-17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.76
transcription factor perturbation	0.74
histone modification site profile	0.69
gene perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Nucleotide Phosphatase / Histidine Triad Nucleotide-binding Protein 2, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Nucleotide Phosphatase / Histidine Triad Nucleotide-binding Protein 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.89   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 123   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.89   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0