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Tbio
JAM3
Junctional adhesion molecule C

Protein Summary
Description
Mediates cell-cell adhesion (PubMed:11590146, PubMed:12208882, PubMed:15194813). Functions as counter-receptor for JAM2 (PubMed:11590146). Functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). May play a role in the regulation of cell migration (Probable). Required for normal polarization and acrosome formation in developing spermatids, and for normal male fertility (By similarity). Soluble form of JAM-C: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299106
  • ENSP00000299106
  • ENSG00000166086
  • ENST00000441717
  • ENSP00000395742

Symbol
  • JAMC
  • JAM-2
  • JAM-3
  • JAM-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
PubMedID
0.8
protein domain
0.73
biological process
0.71
tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.22   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.22   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.968
Data Source:  Reactome,STRINGDB
JAM2
Tbio
Novelty:  0.02059056
Score:  0.965
Data Source:  Reactome,STRINGDB
ITGA4
Tclin
Novelty:  0.00197607
Score:  0.951
Data Source:  Reactome,STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.94
Data Source:  Reactome,STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.94
Data Source:  Reactome,STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.94
Data Source:  Reactome,STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.938
Data Source:  STRINGDB
IGSF5
Tbio
Novelty:  0.11695258
Score:  0.931
Data Source:  STRINGDB
GORASP2
Tbio
Novelty:  0.02121907
Score:  0.845
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Extracellular matrix organization
Hemostasis
Integrin cell surface interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
2
1.1
57.2
neutrophil count
1
1
1
44.2
age at first sexual intercourse measurement
1
1
1
15.8
self reported educational attainment
1
1
1
7
intelligence
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
57.2
neutrophil count
1
44.2
age at first sexual intercourse measurement
1
15.8
self reported educational attainment
1
7
intelligence
1
7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
junctional adhesion molecule 3
VGNC:11845
451678
Macaque
junctional adhesion molecule 3
694042
Mouse
MGI:1933825
83964
Rat
RGD:1303248
315509
Dog
junctional adhesion molecule 3
VGNC:53419
489271
Species
Name
OMA
EggNOG
Inparanoid
Chimp
junctional adhesion molecule 3
Macaque
junctional adhesion molecule 3
Mouse
Rat
Dog
junctional adhesion molecule 3
Publication Statistics
PubMed Score 128.22
PubMed score by year
PubTator Score 59.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title