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Tbio
SORBS1
Sorbin and SH3 domain-containing protein 1

Protein Summary
Description
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277982
  • ENSP00000277982
  • ENSG00000095637
  • ENST00000306402
  • ENSP00000302556
  • ENST00000354106
  • ENSP00000277984
  • ENST00000361941
  • ENSP00000355136
  • ENST00000371227
  • ENSP00000360271
  • ENST00000371239
  • ENSP00000360283
  • ENST00000371241
  • ENSP00000360285
  • ENST00000371245
  • ENSP00000360291
  • ENST00000371246
  • ENSP00000360292
  • ENST00000371247
  • ENSP00000360293
  • ENST00000371249
  • ENSP00000360295
  • ENST00000607232
  • ENSP00000475901

Symbol
  • KIAA0894
  • KIAA1296
  • SH3D5
  • CAP
  • FLAF2
  • R85FL
  • SH3D5
  • SORB1
  • SH3P12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor
0.91
biological process
0.88
kinase perturbation
0.84
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.41   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.41   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
63.7
red blood cell density measurement
1
1
1
56.9
glomerular filtration rate
1
1
1
31.4
mean platelet volume
1
1
1
24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
63.7
red blood cell density measurement
1
56.9
glomerular filtration rate
1
31.4
mean platelet volume
1
24
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorbin and SH3 domain containing 1
VGNC:12506
450628
Mouse
MGI:700014
20411
Dog
sorbin and SH3 domain containing 1
VGNC:46657
100686806
Horse
sorbin and SH3 domain containing 1
VGNC:23445
100061292
Pig
sorbin and SH3 domain containing 1
100153151
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorbin and SH3 domain containing 1
Mouse
Dog
sorbin and SH3 domain containing 1
Horse
sorbin and SH3 domain containing 1
Pig
sorbin and SH3 domain containing 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BX66-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Protein-Protein Interactions (165)
1 – 10 of 165
VCL
Tbio
Novelty: 0.00043107
Score: 0.987
Data Source: STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.974
Data Source: STRINGDB
INSR
Tclin
Family: Kinase
Novelty: 0.00230617
Score: 0.969
Data Source: STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.962
Data Source: STRINGDB
AFDN
Tbio
Novelty: 0.00372947
Score: 0.96
Data Source: STRINGDB
SH2B2
Tbio
Novelty: 0.20893668
Score: 0.955
Data Source: STRINGDB
RAPGEF1
Tbio
Novelty: 0.00365765
Score: 0.946
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.939
Data Source: STRINGDB
ITGA1
Tbio
Novelty: 0.00545805
Score: 0.931
Data Source: STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.41

PubMed score by year
PubTator Score  27.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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