Tbio SORBS1 Sorbin and SH3 domain-containing protein 1

Protein Summary

Description

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9BX66
• A0AED4
• A6NEK3
• A6NID8
• A6NJS4
• A7MD40
• D3DR42
• O43857
• Q5T923
• Q5T924
• Q5T927
• Q5T928
• Q5T929
• Q5T930
• Q5T931
• Q5T932
• Q7LBE5
• Q8IVK0
• Q8IVQ4
• Q96KF3
• Q96KF4
• Q9BX64
• Q9BX65
• Q9P2Q0
• Q9UFT2
• Q9UHN7
• Q9Y338

Gene Name

• SORBS1

Ensembl ID

• ENST00000277982
• ENSP00000277982
• ENSG00000095637
• ENST00000306402
• ENSP00000302556
• ENST00000354106
• ENSP00000277984
• ENST00000361941
• ENSP00000355136
• ENST00000371227
• ENSP00000360271
• ENST00000371239
• ENSP00000360283
• ENST00000371241
• ENSP00000360285
• ENST00000371245
• ENSP00000360291
• ENST00000371246
• ENSP00000360292
• ENST00000371247
• ENSP00000360293
• ENST00000371249
• ENSP00000360295
• ENST00000607232
• ENSP00000475901

Symbol

• KIAA0894
• KIAA1296
• SH3D5
• CAP
• FLAF2
• R85FL
• SH3D5
• SORB1
• SH3P12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
transcription factor	0.91
biological process	0.88
kinase perturbation	0.84
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.94   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 249   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.94   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0