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Tbio
BRIP1
Fanconi anemia group J protein

Protein Summary
Description
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259008
  • ENSP00000259008
  • ENSG00000136492
  • ENST00000577598
  • ENSP00000464654

Symbol
  • BACH1
  • FANCJ
  • OF
  • BACH1
  • FANCJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
virus perturbation
0.92
histone modification site profile
0.87
protein domain
0.85
transcription factor binding site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.08   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.08   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (164)
MLH1
Tbio
Novelty:  0.00034212
p_int:  0.99999956
p_ni:  3.34e-7
p_wrong:  1.06e-7
Score:  0.961
Data Source:  BioPlex,STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.999975509
p_ni:  0.000024491
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.997106045
p_ni:  0.002893955
Data Source:  BioPlex
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.996230146
p_ni:  0.003769842
p_wrong:  1.2e-8
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.984021932
p_ni:  0.015978055
p_wrong:  1.3e-8
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.982631491
p_ni:  0.017368504
p_wrong:  6e-9
Data Source:  BioPlex
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.98166921
p_ni:  0.018330779
p_wrong:  1.1e-8
Data Source:  BioPlex
C10orf91
Tdark
p_int:  0.979714132
p_ni:  0.020206045
p_wrong:  0.000079823
Data Source:  BioPlex
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.964224775
p_ni:  0.035766904
p_wrong:  0.00000832
Data Source:  BioPlex
DRC3
Tdark
Novelty:  0.99283468
p_int:  0.943995827
p_ni:  0.055920826
p_wrong:  0.000083347
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cytosolic iron-sulfur cluster assembly
DNA Double-Strand Break Repair
DNA Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
61.4
1
1
0
8
56.6
self reported educational attainment
1
1
1
53.7
mean corpuscular volume
1
1
1
53.3
mathematical ability
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
61.4
0
8
56.6
self reported educational attainment
1
53.7
mean corpuscular volume
1
53.3
mathematical ability
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRCA1 interacting protein C-terminal helicase 1
VGNC:9816
454796
Macaque
BRCA1 interacting protein C-terminal helicase 1
712408
Mouse
MGI:2442836
237911
Dog
BRCA1 interacting protein C-terminal helicase 1
VGNC:38530
491122
Cow
BRCA1 interacting protein C-terminal helicase 1
VGNC:50067
783256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRCA1 interacting protein C-terminal helicase 1
Macaque
BRCA1 interacting protein C-terminal helicase 1
Mouse
Dog
BRCA1 interacting protein C-terminal helicase 1
Cow
BRCA1 interacting protein C-terminal helicase 1
Publication Statistics
PubMed Score 103.08
PubMed score by year
PubTator Score 96.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title