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Tbio
RBM24
RNA-binding protein 24

Protein Summary
Description
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318204
  • ENSP00000319551
  • ENSG00000112183
  • ENST00000379052
  • ENSP00000368341
  • ENST00000425446
  • ENSP00000396898

Symbol
  • RNPC6
  • RNPC6
  • dJ259A10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.74
histone modification site profile
0.72
microRNA
0.71
tissue sample
0.61
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.75   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.75   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (98)
1 – 10 of 98
RBM38
Tbio
Novelty: 0.04146599
p_int: 0.999997915
p_ni: 0.000002076
p_wrong: 8e-9
Score: 0.249
Data Source: BioPlex,STRINGDB
DMKN
Tbio
Novelty: 0.14733652
p_int: 0.999491475
p_ni: 0.000042301
p_wrong: 0.000466223
Score: 0.214
Data Source: BioPlex,STRINGDB
IVL
Tbio
Novelty: 0.00154231
p_int: 0.999196487
p_ni: 0.000803506
p_wrong: 7e-9
Data Source: BioPlex
TRIM29
Tbio
Novelty: 0.03164477
p_int: 0.998813376
p_ni: 0.001186623
Data Source: BioPlex
SERPINB2
Tbio
Novelty: 0.00223708
p_int: 0.998637066
p_ni: 0.001358526
p_wrong: 0.000004409
Data Source: BioPlex
SERPINB5
Tbio
Novelty: 0.00088182
p_int: 0.998406023
p_ni: 0.001593977
Data Source: BioPlex
CRYAB
Tbio
Novelty: 0.00547363
p_int: 0.99785669
p_ni: 0.00214331
Score: 0.169
Data Source: BioPlex,STRINGDB
PKP3
Tbio
Novelty: 0.03295269
p_int: 0.997821465
p_ni: 0.002177039
p_wrong: 0.000001496
Data Source: BioPlex
PPL
Tbio
Novelty: 0.00404743
p_int: 0.996926543
p_ni: 0.003073457
Score: 0.158
Data Source: BioPlex,STRINGDB
SERPINB13
Tbio
Novelty: 0.03180119
p_int: 0.995312346
p_ni: 0.004687635
p_wrong: 1.9e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  21.75

PubMed score by year
PubTator Score  7.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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