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Tbio
GTPBP2
GTP-binding protein 2

Protein Summary
Description
GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.[supplied by OMIM, Jan 2003]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307114
  • ENSP00000304893
  • ENSG00000172432
  • ENST00000307126
  • ENSP00000303997

Symbol
  • JABELS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
virus perturbation
0.97
transcription factor perturbation
0.96
molecular function
0.91
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.999828639
p_ni:  0.000171361
Data Source:  BioPlex
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.999773524
p_ni:  0.000226476
Score:  0.226
Data Source:  BioPlex,STRINGDB
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
p_int:  0.999515577
p_ni:  0.000388018
p_wrong:  0.000096404
Score:  0.169
Data Source:  BioPlex,STRINGDB
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
p_int:  0.996139391
p_ni:  0.003860609
Score:  0.177
Data Source:  BioPlex,STRINGDB
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.98179993
p_ni:  0.018200037
p_wrong:  3.2e-8
Data Source:  BioPlex
MUC20
Tbio
Novelty:  0.04645313
p_int:  0.980927315
p_ni:  0.018928246
p_wrong:  0.000144439
Data Source:  BioPlex
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.977657033
p_ni:  0.022342811
p_wrong:  1.56e-7
Data Source:  BioPlex
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.888131652
p_ni:  0.109977204
p_wrong:  0.001891144
Data Source:  BioPlex
IGFBP1
Tchem
Novelty:  0.0006975
p_int:  0.875855769
p_ni:  0.122356224
p_wrong:  0.001788007
Data Source:  BioPlex
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.852333089
p_ni:  0.146621748
p_wrong:  0.001045162
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
52.7
body mass index
2
1
2
52
body height
1
1
1
30.2
refractive error measurement
1
1
1
17.8
leukocyte count
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
52.7
body mass index
2
52
body height
1
30.2
refractive error measurement
1
17.8
leukocyte count
1
12.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 2
VGNC:2853
472015
Macaque
GTP binding protein 2
700913
Mouse
MGI:1860138
56055
Rat
RGD:1306367
363195
Dog
GTP binding protein 2
VGNC:41558
481818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 2
Macaque
GTP binding protein 2
Mouse
Rat
Dog
GTP binding protein 2
Publication Statistics
PubMed Score 11.13
PubMed score by year
PubTator Score 3.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title